Dr. Umut BARBAROS

Doctor Information

• 1997-2003 Marmara University, Marmara Medical Faculty, Medical Doctor
• 2003-2008 Istanbul University, Istanbul Medical Faculty, Department of General Surgery
• 2006-2007 University of Catania, Department of General Surgery, Italy, Master’s Program in Minimally Invasive Surgery and Modern Techniques in Surgery
• 2008-2014 Istanbul University, Istanbul Medical Faculty, Associate Professor
• 2014 Istanbul University, Istanbul Medical Faculty, Professor

Areas of Expertise

Publications

• ARTICLES PUBLISHED IN INTERNATIONAL PEER-REVIEWED JOURNALS Title: Cancer Frequency in Retrosternal Goiter Author(s): Sahbaz, NA (Sahbaz, Nuri A.); Tutal, F (Tutal, Firat); Aksakal, N (Aksakal, Nihat); Acar, S (Acar, Sami); Aksu, KI (Aksu, Kadir I.); Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim) Source: AMERICAN SURGEON Volume: 83 Issue: 12 Pages: 1390-1393 Published: DEC 2017 Abstract: Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Three hundred and ninety consecutive patients, who had surgery because of retrosternal goiter in Istanbul University Medical Faculty Department of General Surgery between 2005 and 2015 were included in the study (Group 1). Control group included 880 patients who had surgery because of nontoxic multinodular goiter in the same period (Group 2). Preoperative ultrasonography (USG) was performed to each patient. Fine-needle aspiration biopsy was performed in suspicious nodules and results were recorded. Carcinomas in histopathological examination were classified as intrathorasic and extrathorasic. Diagnostic rates of USG results were compared with histopathologic cancer results. Papillary carcinoma was diagnosed in 76 patients with retrosternal goiter (19%) and in 200 patients in the control group (22%). No statistically significant difference was detected between groups regarding the tumor rates (P > 0.05). One hundred and forty-four tumoral foci were detected in 76 patients with papillary carcinoma in retrosternal goiter patients. Three hundred and seventy tumoral foci were detected in 200 patients with papillary carcinoma in the control group. In the retrosternal goiter group, 104 carcinoma lesions of 144 papillary carcinomas were intrathorasic (72%). No statistically significant difference was detected between intrathorasic (2.1 +/- 1 cm) and extrathorasic regiones (1.9 +/- 0.8 cm) regarding the tumor size P > 0.05. When patients with and without cancer in the retrosternal goiter group were compared regarding familial thyroid cancer history, radiation to the neck, and cervical adenopathy, no statistically significant difference was detected. Cancer incidence of retrosternal goiters was not higher than that of the cervical ones. Yet, cancer foci of retrosternal goiters were commonly located in the intrathorasic area and were not detected with USG. Depending on these findings, we suggest that all retrosternal goiters should be surgically treated. Accession Number: WOS:000425216300024 PubMed ID: 29336760 ISSN: 0003-1348 eISSN: 1555-9823 Title: Minimally invasive distal pancreatectomy A retrospective review of 30 cases Author(s): Sumer, A (Sumer, Aziz); Barbaros, U (Barbaros, Umut); Conde, SM (Conde, Salvador Morales); Celik, S (Celik, Sebahattin); Aksakal, N (Aksakal, Nihat); Alamo, JM (Alamo, Jose Maria); Alarcon, I (Alarcon, Isaias); Gures, N (Gures, Nazim); Karayagiz, H (Karayagiz, Hamit); Dinccag, A (Dinccag, Ahmet); Seven, R (Seven, Ridvan); Mercan, S (Mercan, Selcuk); Budak, D (Budak, Demir) Source: ANNALI ITALIANI DI CHIRURGIA Volume: 88 Issue: 2 Pages: 122-128 Article Number: PII S0003469X17026410 Published: MAR-APR 2017 Abstract: OBJECTIVES: Pancreatic surgery has been greatly influenced by the advent of laparoscopic surgery and increasing experience in its performance and by advances in techniques and surgical devices. This study aimed to represent two centers' initial experiences in laparoscopic distal pancreatic surgery. METHODS: This study was a bi-centric study including 30 patients undergoing distal pancreatectomy for pancreatic disorders. All the patients were operated on from November 2006 to November 2013 in Turkey and Spain. RESULTS: Laparoscopic spleen-preserving distal pancreatectomy was performed in 9 patients, laparoscopic distal pancreatectomy was performed in 14 patients, laparoscopic enucleation was performed in 4 patients, and single-incision laparoscopic distal pancreatosplenectomy with splenectomy was performed in 3 patients. CONCLUSIONS: Laparoscopic distal pancreatectomies for pancreatic disorders are feasible and safe procedures if performed by experienced laparoscopic surgeons. Accession Number: WOS:000400724600005 ISSN: 0003-469X eISSN: 2239-253X Title: Magnetic Probe-Guided Excision of Nonpalpable Neck Lesions: A New and Safe Technique for Operated Neck Compartments Author(s): Aksakal, N (Aksakal, Nihat); Ozturk, A (Ozturk, Alper); Tutal, F (Tutal, Firat); Dogan, S (Dogan, Selim); Agcaoglu, O (Agcaoglu, Orhan); Bulakci, M (Bulakci, Mesut); Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim) Source: SURGICAL INNOVATION Volume: 24 Issue: 1 Pages: 42- 48 DOI: 10.1177/1553350616676444 Published: FEB 2017 Abstract: Background: Reoperative neck surgery is technically more demanding because of the presence of scar tissue and distorted anatomy. We aimed to investigate the magnetic probe-guided excision of nonpalpable neck lesions in patients with previously operated neck compartments. Methods: This study included 9 patients with recurrent/persistent thyroid carcinoma, recurrent/persistent hyperparathyroidism with previously operated neck compartments. The pathologic lesions were localized by ultrasonography, and magnetic tracer (0.2 mL, iron oxide) was injected directly into the pathologic lesions. Careful dissection was carried out following the area of maximum magnetic activity until the nonpalpable lesions were identified and excised. Result: All neck lesions were removed in 9 patients. The median count from lesion was significantly higher than values from lesion bed (background activity; (9900/5 seconds vs 250/5 seconds, P < .001). During follow-up, all patients had negative ultrasonography. Conclusion: Magnetic probe-guided technique could provide access to nonpalpable lesion localization in centers without readily available access to nuclear medicine facilities. Accession Number: WOS:000394903900006 PubMed ID: 27815341 ISSN: 1553-3506 eISSN: 1553-3514 Title: Thyroid cancer incidence in simultaneous thyroidectomy with parathyroid surgery Author(s): Emirikci, S (Emirikci, Selman); Ozcinar, B (Ozcinar, Beyza); Oner, G (Oner, Gizem); Omarov, N (Omarov, Nail); Agcaoglu, O (Agcaoglu, Orhan); Soytas, Y (Soytas, Yigit); Aksakal, N (Aksakal, Nihat); Yanar, F (Yanar, Fatih); Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim) Source: TURKISH JOURNAL OF SURGERY Volume: 31 Issue: 4 Pages: 214- 217 DOI: 10.5152/UCD.2015.2666 Published: DEC 2015 Abstract: Objective: Primary hyperparathyroidism (PHPT) is often seen in conjunction with an underlying thyroid disorder. Imaging methods that are used to localize the parathyroid adenoma also detect associated thyroid nodules and thyroid cancer. The aim of this study was to detect the rate of thyroid cancer identified while performing parathyroidectomy and thyroidectomy in patients with PHPT. Material and Methods: Files of all patients who were operated for PHPT and who underwent simultaneous thyroidectomy were analyzed. Data regarding parathyroid pathology, surgical procedures, indications of thyroid surgery, and pathology results were retrospectively recorded. The indications for thyroid surgery included presence of suspicious thyroid nodules in ultrasonography, increase in size of thyroid nodules in follow-up ultrasound, or presence of suspicious thyroid fine needle aspiration biopsy (FNAB) findings. Rates of thyroid cancer detection were investigated according to definite pathology reports. Results: Eighty-three patients who underwent parathyroidectomy with a diagnosis of PHPT with concurrent thyroidectomy in Department of General Surgery, Istanbul University Istanbul Faculty of Medicine were included in the study. Eighteen patients were male (22%) and 65 were female (78%). The median age was 53 (18-70) years. The primary indication for parathyroidectomy was primary hyperparathyroidism in all patients. The thyroid procedures applied in addition to parathyroidectomy were lobectomy + isthmusectomy in 29 patients (35%), bilateral subtotal thyroidectomy in 20 patients (24%), bilateral total thyroidectomy in 23 patients (28%), and total thyroidectomy on one side and near total thyroidectomy to the other side in 11 patients (13%). The only indication for thyroidectomy was the presence of thyroid nodules until 2000 (20 patients, 24%). Indications in the remaining 63 patients included the presence of multiple nodules that cannot be followed up by ultrasonography in 25 patients (30%), presence of a suspicious nodule on ultrasonography in 33 patients (40%), growth in nodule size in 2 patients (2%), and detection of suspicious findings on FNAB in 3 patients (4%). Five patients (6%) were diagnosed with papillary thyroid cancer, four of whom were micropapillary cancer. Conclusion: Imaging methods performed to localize the pathological parathyroid gland for a diagnosis of PHPT are useful in estimating other accompanying pathologies. Presence of thyroid nodules should be evaluated before all parathyroid procedures, and if the nodule has an indication for surgery, thyroid surgery should be considered at the same operation with parathyroid surgery. Accession Number: WOS:000370846700007 PubMed ID: 26668529 ISSN: 1300-0705 eISSN: 1308-8521 Title: Comparison of single port and three port laparoscopic splenectomy in patients with immune thrombocytopenic purpura: Clinical comparative study Author(s): Barbaros, U (Barbaros, Umut); Aksakal, N (Aksakal, Nihat); Tukenmez, M (Tukenmez, Mustafa); Agcaoglu, O (Agcaoglu, Orhan); Bostan, MS (Bostan, Mustafa Sami); Kilic, B (Kilic, Berkay); Kalayci, M (Kalayci, Murat); Dinccag, A (Dinccag, Ahmet); Seven, R (Seven, Ridvan); Mercan, S (Mercan, Selcuk) Source: JOURNAL OF MINIMAL ACCESS SURGERY Volume: 11 Issue: 3 Pages: 172- 176 DOI: 10.4103/0972-9941.159853 Published: JUL-SEP 2015 Abstract: AIM: Single-port laparoscopic surgery (SILS) has become increasingly popular during the last decades. This prospective study was undertaken to evaluate the feasibility of single-port laparoscopic splenectomy compared with conventional multiport laparoscopic splenectomy. MATERIALS AND METHODS: Between February 2, 2009 and August 29, 2011, a total of 40 patients with the diagnosis of immune thrombocytopenic purpura were included to study. Patients were alienated into two groups according to the procedure type including SILS and conventional multiport splenectomy. RESULTS: There were 19 patients in group 1, and 21 in group 2. Operative time was significantly shorter in group 1 versus group 2 (112.4 +/- 13.56 vs 71.2 +/- 18.1 minutes, respectively, P < 0.05). One patient in group 1 had converted to laparatomy due to preoperative bleeding. Postoperative pain analyses (VAS Score) revealed superiority of SILS in the early post-operative days (P < 0.05). CONCLUSIONS: SILS splenectomy is a safe and effective alternative to standard laparoscopic splenectomy. Accession Number: WOS:000357738100002 PubMed ID: 26195874 ISSN: 0972-9941 eISSN: 1998-3921 Title: Safety and feasibility of laparoscopic adrenalectomy: What is the role of tumour size? A single institution experience Author(s): Aksakal, N (Aksakal, Nihat); Agcaoglu, O (Agcaoglu, Orhan); Barbaros, U (Barbaros, Umut); Tukenmez, M (Tukenmez, Mustafa); Dogan, S (Dogan, Selim); Kilic, B (Kilic, Berkay); Erbil, Y (Erbil, Yesim); Seven, R (Seven, Ridvan); Ozarmagan, S (Ozarmagan, Selcuk); Mercan, S (Mercan, Selcuk) Source: JOURNAL OF MINIMAL ACCESS SURGERY Volume: 11 Issue: 3 Pages: 184- 186 DOI: 10.4103/0972-9941.144091 Published: JUL-SEP 2015 Abstract: BACKGROUND: Although, there are studies in the literature having shown the feasibility and safety of laparoscopic adrenalectomy, there are still debates for tumour size and the requirement of the minimal invasive approach. Our hypothesis was that the use of laparoscopy facilitates minimally invasive resection of large adrenal tumours regardless of tumour size. Materials and Methods: Within 7 years, 149 patients underwent laparoscopic adrenalectomy at one institution. The patients were divided into two study groups according to tumour size. Group 1 included patients with adrenal tumours smaller than 5 cm and group 2 included larger than 5 cm. Patient demographics and clinical parameters, operative time, complications, hospital stay and final pathology were analysed. Statistical analyses of clinical and perioperative parameters were performed using Student's t-test and Chi-square tests. RESULTS: There were 88 patients in group 1 and 70 in group 2. There were no significant differences between study groups regarding patient demographics, operative time, hospital stay, and complications. Estimated blood loss was significantly higher in group 2 (P = 0.002). The conversion to open rate was similar between study groups with 5.6% versus 4.2%, respectively. Pathology was similar between groups. CONCLUSION: Our study shows that the use laparoscopy for adrenal tumours larger than 5 cm is a safe and feasible technique. Laparoscopic adrenalectomy is our preferred minimally invasive surgical approach for removing large adrenal tumours. Accession Number: WOS:000357738100004 PubMed ID: 26195876 ISSN: 0972-9941 eISSN: 1998-3921 Title: The comparison of single incision laparoscopic cholecystectomy and three port laparoscopic cholecystectomy: prospective randomized study Author(s): Deveci, U (Deveci, Ugur); Barbaros, U (Barbaros, Umut); Kapakli, MS (Kapakli, Mahmut Sertan); Manukyan, MN (Manukyan, Manuk Norayk); Simsek, S (Simsek, Selcuk); Kebudi, A (Kebudi, Abut); Mercan, S (Mercan, Selcuk) Source: JOURNAL OF THE KOREAN SURGICAL SOCIETY Volume: 85 Issue: 6 Pages: 275- 282 DOI: 10.4174/jkss.2013.85.6.275 Published: DEC 2013 Abstract: Purpose: Laparoscopic techniques have allowed surgeons to perform complicated intraabdominal surgery with minimal trauma. Single incision laparoscopic surgery (SILS) was developed with the dim of reducing the invasiveness of conventional laparoscopy. In this study we aimed to compare results of SILS cholecystectomy and three port conventional laparoscopic (TPCL) cholecystectomy prospectively. Methods: In this prospective study, 100 patients who underwent laparoscopic cholecystectomy for gallbladder disease were randomly allocated to SILS cholecystectomy (group 1) or TPCL cholecystectomy (group 2). Demographics, pathologic diagnosis, operating time, blood loss, length of hospital stay, complications, pain score, conversion rate, and satisfaction of cosmetic outcome were recorded. Results: Forty-four SILS cholesystectomies (88%) and 42 TPCL cholecystectomies (84%) were completed successfully. Conversion to open surgery was required for 4 cases in group 1 and 6 cases in group 2. Operating time was significantly longer in group 1 compared with group 2 (73 minutes vs. 48 minutes; P < 0.05). Higher pain scores were observed in group 1 versus group 2 in postoperative day 1 (P < 0.05). There was higher cosmetic satisfaction in group 1 (P < 0.05). Conclusion: SILS cholecystectomy performed by experienced surgeons is at least as successful, feasible, effective and safe as a TPCL cholecystectomy. Surgeons performing SILS should have a firm foundation of advanced minimal access surgical skills and a cautious, gradated approach to attempt the various procedures. Prospective randomized studies comparing single access versus conventional multiport laparoscopic cholecystectomy, with large volumes and long-term followup, are needed to confirm our initial experience. (ClinicalTrials.gov Identifier: NCT01772745.) Accession Number: WOS:000327682600004 PubMed ID: 24368985 ISSN: 2233-7903 eISSN: 2093-0488 Title: Laparoscopic Surgery of the Splenic Artery and Vein Aneurysm With Spontaneous Arteriovenous Fistula Author(s): Barbaros, U (Barbaros, Umut); Ozemir, IA (Ozemir, Ibrahim A.); Aksakal, N (Aksakal, Nihat); Tukenmez, M (Tukenmez, Mustafa); Kilic, B (Kilic, Berkay); Agcaoglu, O (Agcaoglu, Orhan); Dinccag, A (Dinccag, Ahmet); Seven, R (Seven, Ridvan); Mercan, S (Mercan, Selcuk) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 23 Issue: 3 Pages: E127- E130 DOI: 10.1097/SLE.0b013e31827775f2 Published: JUN 2013 Abstract: Visceral artery aneurysms are rare and important vascular entities due to the quarter of all cases presented as surgical emergency. Nevertheless, splenic artery aneurysm (SAA) is the most common visceral and third most common intra-abdominal artery aneurysm after aorta and iliac artery. SAA accompany splenic vein aneurysm because arteriovenous fistula communication between them is a very rare entity. Location and size of the SAA determine the likelihood of rupture. Women of child-bearing age who have SAAs are at particularly high risk of death as a result of aneurysm rupture and should be treated with elective repair. Herein, we report a case of a splenic artery and vein aneurysm with arteriovenous fistula in a 25-year-old young female patient who presented with left upper quadrant pain. Diagnosis was established by computerized tomography angiogram. The patient underwent laparoscopic resection of splenic artery and vein, as well as with splenectomy. Laparoscopic therapy for SAA should be considered for the patient with a low periprocedural morbidity at experienced surgical clinics. Accession Number: WOS:000330530300011 PubMed ID: 23752021 ISSN: 1530-4515 eISSN: 1534-4908 Title: Nonfunctional adrenal lesions without loss of signal intensity on MRI: Whose problem is it? The patient's? The surgeon's? Author(s): Aksakal, N (Aksakal, Nihat); Sahbaz, A (Sahbaz, Alper); Ozcinar, B (Ozcinar, Beyza); Ozemir, A (Ozemir, Ali); Caglayan, K (Caglayan, Kasim); Agcaoglu, O (Agcaoglu, Orhan); Barbaros, U (Barbaros, Umut); Salmaslioglu, A (Salmaslioglu, Artur); Erbil, Y (Erbil, Yesim) Source: INTERNATIONAL JOURNAL OF SURGERY Volume: 11 Issue: 2 Pages: 169- 172 DOI: 10.1016/j.ijsu.2012.12.014 Published: 2013 Abstract: Background: Current indications for adrenalectomy include functional adrenal tumors and potentially malignant tumors based on imaging studies. We evaluated the effectiveness of magnetic resonance imaging (MRI) in obtaining a correct preoperative diagnosis. Method: Fifty-three patients with nonfunctional adrenal lesions were analyzed. Indications for adrenalectomy of nonfunctional adrenal lesions included >6 cm in size and <= 6 cm in size with atypical characteristics on MRI. Lesions with a size of >6 cm, local invasion, irregular margins, and chemical-shift imaging that demonstrated no loss of signal intensity on out-of-phase images were considered suspected of malignancy. Results: Adrenal lesions of >6 cm in size exhibited an 80-fold increased prediction of malignancy (OR: 80; 95% CI 7.8-813), whereas irregular margins and local invasion exhibited a 45-fold (OR: 45; 95% CI 6.4-312.5) and a 12-fold (OR: 12; 95% CI 4.6-30.6) increased occurrence of malignancy, respectively. The loss of signal intensity did not affect the prediction of malignancy. Conclusion: The rate of unnecessary tumor resections that are <6 cm in size can be decreased by performing adrenal biopsies in selected cases or by short-term follow-up to prevent the insufficiency of imaging techniques. (C) 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. Accession Number: WOS:000316937200012 PubMed ID: 23274279 ISSN: 1743-9191 Title: Laparoscopic Transperitoneal Partial Nephrectomy for Renal Hydatid Cyst: A Case Report Author(s): Mercan, S (Mercan, Selcuk); Loh, WL (Loh, Wei-Liang); Gur, E (Gur, Ertugrul); Pehlivanoglu, T (Pehlivanoglu, Tolga); Barbaros, U (Barbaros, Umut) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 22 Issue: 4 Pages: E206- E208 DOI: 10.1097/SLE.0b013e31824eda3c Published: AUG 2012 Abstract: A 29-year-old female patient with an isolated hydatid cyst in the lower pole of the left kidney presented with a history of weight loss and cloudy, foul-smelling urine. Laparoscopic partial nephrectomy was performed, at which the cyst was removed en bloc. On the fifth postoperative day, she was discharged without any complication. Nine months postoperatively, a computed tomography scan revealed no recurrence of hydatidosis. Accession Number: WOS:000307671400009 PubMed ID: 22874701 ISSN: 1530-4515 Title: Single-port transumbilical laparoscopic cholecystectomy: A prospective randomised comparison of clinical results of 140 cases Author(s): Vilallonga, R (Vilallonga, Ramon); Barbaros, U (Barbaros, Umut); Sumer, A (Sumer, Aziz); Demirel, T (Demirel, Tugrul); Fort, JM (Manuel Fort, Jose); Gonzalez, O (Gonzalez, Oscar); Rodriguez, N (Rodriguez, Nivardo); Carrasco, MA (Armengol Carrasco, Manuel) Source: JOURNAL OF MINIMAL ACCESS SURGERY Volume: 8 Issue: 3 Pages: 74- 78 DOI: 10.4103/0972-9941.97586 Published: JUL-SEP 2012 Abstract: Introduction: A novel single port access (SPA) cholecystectomy approach is described in this study. We have designed a randomised comparative study in order to elucidate any possible differences between the standard treatment and this novel technique. Materials and Methods: Between July 2009 and March 2010, 140 adult patients with gallbladder pathologies were enrolled in this multicentre study. Two surgeons (RV and UB) randomised patients to either a standard laparoscopic (SL) approach group or to an SPA cholecystectomy group. Two types of trocars were used for this study: the TriPort (TM) and the SILS (TM) Port. Outcomes including blood loss, operative time, complications, length of stay and pain were recorded. Results: There were 69 patients in the SPA group and 71 patients in the SL group. The mean age of the patients was 43.2 (17-77) for the SPA group and 42.6 (19-70) for the SL group. The mean operative time was 63.9 min in the SPA group and 58.4 min in the SL group. For one patient, the SPA procedure was converted to a standard laparoscopic technique and to open approach in the SL group. Complications occurred in eight patients: Five seromas (two in the SPA group) and three hernias (one in the SPA group).The mean hospital stay was 38.5 h in the SPA group and 24.1 h in the SL group. Pain was evaluated and was 2 in the SPA and 2.9 in the SL group, according to the visual analogue scale (VAS) after 24 h (P < 0.001). The degree of satisfaction was higher in the SPA group (8.3 versus 6.7). Similar results were found for the aesthetic result (8.8 versus 7.5). (P < 0.001). Conclusion: Single-port transumbilical laparoscopic cholecystectomy can be feasible and safe. When technical difficulties arise, early conversion to a standard laparoscopic technique is advised to avoid serious complications. The SPA approach can be undertaken without the expense of additional operative time and provides patients with minimal scarring. The cosmetic results and the degree of satisfaction appear to be significant for the SPA approach. Accession Number: WOS:000306275900002 PubMed ID: 22837593 Author Identifiers: Author ResearcherID Number ORCID Number RODRIGUEZ CONDE, NIVARDO 0000-0003-0132-2928 VILALLONGA, RAMON 0000-0001-9333-2765 ISSN: 0972-9941 Title: Single Incision Laparoscopic Splenectomy: Our First Experiences Author(s): Barbaros, U (Barbaros, Umut); Sumer, A (Sumer, Aziz); Dinccag, A (Dinccag, Ahmet); Batman, B (Batman, Burcin); Mercan, S (Mercan, Selcuk); Seven, R (Seven, Ridvan); Demir, B (Demir, Budak) Source: BALKAN MEDICAL JOURNAL Volume: 28 Issue: 2 Pages: 129- 132 DOI: 10.5174/tutfd.2009.02985.4 Published: JUN 2011 Abstract: Objective: Most laparoscopic surgeons have attempted to reduce incisional morbidity and improve cosmetic outcomes by using less and smaller trocars. Single incision laparoscopic splenectomy is a new laparoscopic procedure. Herein we would like to present our experiences. Material and Methods: Between January 2009 and June 2009, data of the 7 patients who underwent single incision laparoscopic splenectomy were evaluated retrospectively. Results: There were 7 patients (5 females and 2 males) with a mean age of 29.9 years. The most common splenectomy indication was idiopathic thrombocytopenic purpura. Single incision laparoscopic splenectomy was performed successfully in 6 patients. In one patient the operation was converted to an open procedure. Conclusion: With surgeons experienced in minimally invasive surgery, single incision laparoscopic splenectomy could be performed successfully. However, in order to demonstrate the differneces between standard laparoscopic splenectomy and SILS splenetomy, prospective randomized comparative studies are required. Accession Number: WOS:000293360000004 ISSN: 2146-3123 Title: N-Butyl Cyanoacrylate Versus Conventional Suturing for Fixation of Meshes in an Incisional Hernia Model Author(s): Dilege, E (Dilege, Ece); Deveci, U (Deveci, Ugur); Erbil, Y (Erbil, Yesim); Dinccag, A (Dinccag, Ahmet); Seven, R (Seven, Ridvan); Ozarmagan, S (Ozarmagan, Selcuk); Mercan, S (Mercan, Selcuk); Barbaros, U (Barbaros, Umut) Source: JOURNAL OF INVESTIGATIVE SURGERY Volume: 23 Issue: 5 Pages: 262- 266 DOI: 10.3109/08941939.2010.481008 Published: OCT 2010 Abstract: Background: Chronic pain and related complications reported after the use of perforating fixation devices in hernia surgery have led to the use of tissue sealants. Fibrin sealant is a feasible option for mesh fixation; however data on cyanoacrylate glues are limited. Methods: 32 Sprague-Dawley rats were divided into two groups and a 1.5 cm abdominal wall defect was created on each animal. The lesions were then repaired with 2 x 2 cm polypropylene meshes, fixed with n-butyl-cyanoacrylate in the first group and with polypropylene sutures in the second group. The rats were sacrificed on the 21st and 42nd days. The presence of infection, recurrence, and abdominal adhesions were evaluated, followed by biomechanical testing and histological examination. Results: No mesh infection or hernia recurrences were recorded. There was no statistically significant difference between neither the adhesion scores nor the mean broken pressure of the two groups. Cyanoacrylate sealing was found equivalent to suturing in terms of tissue ingrowth, fibrosis, inflammatory infiltration, abscess formation, and necrosis. Furthermore, cyanoacrylate resulted in less foreign body reaction. Conclusions: Mesh fixation by cyanoacrylate may be considered as an alternative to suture fixation. Accession Number: WOS:000282521800005 PubMed ID: 20874481 ISSN: 0894-1939 Title: Single Incision Laparoscopic Pancreas Resection for Pancreatic Metastasis of Renal Cell Carcinoma Author(s): Barbaros, U (Barbaros, Umut); Sumer, A (Sumer, Aziz); Demirel, T (Demirel, Tugrul); Karakullukcu, N (Karakullukcu, Nazli); Batman, B (Batman, Burcin); Icscan, Y (Icscan, Yalin); Saricam, G (Saricam, Gulay); Serin, K (Serin, Kurcsat); Loh, WL (Loh, Wei-Liang); Dinccag, A (Dinccag, Ahmet); Mercan, S (Mercan, Selcuk) Source: JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS Volume: 14 Issue: 4 Pages: 566- 570 DOI: 10.4293/108680810X12924466008448 Published: OCT-DEC 2010 Abstract: Background: Transumbilical single incision laparoscopic surgery (SILS) offers excellent cosmetic results and may be associated with decreased postoperative pain, reduced need for analgesia, and thus accelerated recovery. Herein, we report the first transumbilical single incision laparoscopic pancreatectomy case in a patient who had renal cell cancer metastasis on her pancreatic corpus and tail. Methods: A 59-year-old female who had metastatic lesions on her pancreas underwent laparoscopic subtotal pancreatectomy through a 2-cm umbilical incision. Results: Single incision pancreatectomy was performed with a special port (SILS port) and articulated equipment. The procedure lasted 330 minutes. Estimated blood loss was 100mL. No perioperative complications occurred. The patient was discharged on the seventh postoperative day with a low-volume (20mL/clay) pancreatic fistula that ceased spontaneously. Pathology result of the specimen was renal cell cancer metastases. Conclusion: This is the first reported SILS pancreatectomy case, demonstrating that even advanced surgical procedures can be performed using the SILS technique in well-experienced centers. Transumbilical single incision laparoscopic pancreatectomy is feasible and can be performed safely in experienced centers. SILS may improve cosmetic results and allow accelerated recovery for patients even with malignancy requiring advanced laparoscopic interventions. Accession Number: WOS:000289960300019 PubMed ID: 21605524 ISSN: 1086-8089 Title: Our Early Experiences With Single-incision Laparoscopic Surgery: The First 32 Patients Author(s): Barbaros, U (Barbaros, Umut); Sumer, A (Sumer, Aziz); Tunca, F (Tunca, Fatih); Gozkun, O (Gozkun, Osman); Demirel, T (Demirel, Tugrul); Bilge, O (Bilge, Orhan); Randazzo, V (Randazzo, Valentina); Dinccag, A (Dinccag, Ahmet); Seven, R (Seven, Ridvan); Mercan, S (Mercan, Selcuk); Budak, D (Budak, Demir) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 20 Issue: 5 Pages: 306- 311 DOI: 10.1097/SLE.0b013e3181f20cf6 Published: OCT 2010 Abstract: Background: Most of the laparoscopic surgeons have been attempting to reduce incisional morbidity and improve cosmetic outcomes by using fewer and smaller ports. Singleincision laparoscopic surgery (SILS) is a new laparoscopic procedure. Herein we would like to present our experiences. Patients and Methods: Between January 2009 and October 2009, data of the 32 patients who were operated through SILS are evaluated prospectively. There were 22 females and 10 males with a mean age of 45.1 +/- 14.8 years. Ten splenectomies for idiopathic thrombocytopenic purpura, 16 cholecystectomies for acute cholecystisis or asymptomatic gallstones, 3 appendectomies for acute apendicitis, one distal pancreatosplenectomy for Renal Cell Cancer metastases, 1 adrenalectomy for Conn Syndrome and 1 case of liver resection for hepatic adenoma were carried out. The most common splenectomy indication was idiopathic trombocytopenic purpura, cholecystectomy indication was acute cholecystitis (n = 8), and asymptomatic cholelithiasis (n = 8), appendectomy indication was acute appendicitis, distal pancreatosplenectomy indication was renal cell cancer metastases, adrenalectomy indication was Conn syndrome and liver resection indication was left hepatic mass in between segments 1 and 2. SILS was carried out successfully in 31 patients. Only in 1 patient conversion was required owing to bleeding. Results: All procedures were carried out through a 2-cm umbilical incision. There was no mortality and morbidity recorded. Conclusions: In experienced hands of minimally invasive surgeons, SILS incision laparoscopic surgery could be carried out successfully in a wide range of surgical operations. However, to be able to show the differences between Standard laparoscopic surgery and single SILS, prospective randomized comparative studies are required. Accession Number: WOS:000283486000012 PubMed ID: 20975500 ISSN: 1530-4515 Title: The Effect of Retroperitoneal Fat Mass on Surgical Outcomes in Patients Performing Laparoscopic Adrenalectomy: The Effect of Fat Tissue in Adrenalectomy Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Sari, S (Sari, Serkan); Agcaoglu, O (Agcaoglu, Orhan); Salmaslioglu, A (Salmaslioglu, Artur); Ozarmagan, S (Ozarmagan, Selcuk) Source: SURGICAL INNOVATION Volume: 17 Issue: 2 Pages: 114- 119 DOI: 10.1177/1553350610365703 Published: JUN 2010 Abstract: Background: Obesity and visceral fat are thought to be the most important factors influencing the technical difficulty during open and laparoscopic surgery. The authors aimed to investigate the effect of retroperitoneal fat mass on surgical outcomes in patients undergoing laparoscopic adrenalectomy. Patients and methods: This prospective study included 51 consecutive patients who underwent lateral transabdominal laparoscopic adrenalectomy. Body mass index (BMI) and retroperitoneal fat area (RFA)/adrenal mass area (AMA) ratio were calculated. Results: There was a positive correlation between BMI and operating time and postoperative complications and hospital stay. According to 2-way analysis of variance, only RFA/AMA ratio (P = .0001) was found to significantly correlate with operating time, whereas BMI did not significantly correlate with operating time (P = .51). In patients with high BMI, high RFA indicated longer operating time and higher complication rate, whereas low RFA was associated with significantly shorter operating time and decreased risk of complications. Conclusion: Retroperitoneal fat mass is a more useful parameter than BMI for predicting the surgical outcomes of laparoscopic adrenalectomy. Accession Number: WOS:000278025400008 PubMed ID: 20504787 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 ISSN: 1553-3506 Title: Prospective randomized comparison of clinical results between hand-assisted laparoscopic and open splenectomies Author(s): Barbaros, U (Barbaros, Umut); Dinccag, A (Dinccag, Ahmet); Sumer, A (Sumer, Aziz); Vecchio, R (Vecchio, Rosario); Rusello, D (Rusello, Domenico); Randazzo, V (Randazzo, Valentina); Issever, H (Issever, Halim); Avci, C (Avci, Cavit) Source: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES Volume: 24 Issue: 1 Pages: 25-32 DOI: 10.1007/s00464-009-0528- x Published: JAN 2010 Abstract: Background Although some studies have compared laparoscopic and hand-assisted laparoscopic splenectomy (HALS) in splenomegaly cases, no study has analyzed the differences between HALS and open splenectomy (OS). This study aimed to compare the HALS and OS techniques in splenomegaly cases. Methods This prospective study included 27 patients undergoing splenectomy for splenic disorders at the Department of General Surgery, Istanbul Medical Faculty between February and October 2007. Open splenectomy was performed for 14 patients and HALS for the remaining 13 patients. Results The end points compared included incision length, operative time, intraoperative blood loss, postoperative drain output and duration, postoperative pain scores, length of postoperative hospitalization, and perioperative complications. The authors found benefits of HALS over OS for incision length, postoperative pain score, postoperative drain output and duration, and hospital stay. The main advantages of the HALS technique over OS were less postoperative pain (p = 0.0002), shorter hospital stay (p = 0.004), and shorter abdominal incision (p = 0.012). Conclusions For splenomegaly, HALS significantly facilitates the surgical procedure and reduces the hospital stay while maintaining the advantages of OS such as tactile sense as well as easy and atraumatic manipulation of enlarged spleens. Accession Number: WOS:000273572200005 PubMed ID: 19551441 ISSN: 0930-2794 Title: Cardiovascular Risk in Patients with Nonfunctional Adrenal Incidentaloma: Myth or Reality? Author(s): Erbil, Y (Erbil, Yesim); Ozbey, N (Ozbey, Nese); Barbaros, U (Barbaros, Umut); Unalp, HR (Unalp, Haluk Recai); Salmaslioglu, A (Salmaslioglu, Artur); Ozarmagan, S (Ozarmagan, Selcuk) Source: WORLD JOURNAL OF SURGERY Volume: 33 Issue: 10 Pages: 2099- 2105 DOI: 10.1007/s00268-009-0178-0 Published: OCT 2009 Abstract: It is not clear whether nonfunctional adrenal incidentaloma (NFA) increases the risk of atherosclerosis and metabolic syndrome or whether this type of adrenal tumor has been found more frequently in patients with cardiometabolic risk factors. We aimed to determine the effects of NFA on cardiometabolic risk factors and endothelial function and to compare the patients with a 1:1 cardiometabolic risk factor matched control group. Thirty-five patients with NFA were studied, and 35 body mass index-, age-, and sex-matched subjects were regarded as group 2 controls. Thirty-five cardiometabolic risk factors-matched subjects were then regarded as group 3 controls. Patients with NFA had significantly lower flow-mediated dilation (FMD)-a parameter for endothelial function-measurements compared with groups 2 and 3 (7.1 +/- A 2.9% vs. 12.9 +/- A 3.8% and 13.5 +/- A 4.5%; P < 0.02). Frequency of metabolic syndrome was also significantly higher in NFA patients than in control groups 2 and 3 (31.4, 5.7, and 20.0%, respectively; P < 0.05). Age (Odds Ratio [OR] = 2.9), total cholesterol (OR = 2.3), and presence of adrenal incidentaloma (OR = 10) were significant independent predictors of lower FMD (P < 0.05 for all). Patients with NFA have increased prevalence of metabolic syndrome and impaired endothelial function compared with 1:1 cardiometabolic risk factor-matched controls. Accession Number: WOS:000269974900021 PubMed ID: 19649755 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 ISSN: 0364-2313 Title: Single Incision Laparoscopic Splenectomy: The First Two Cases Author(s): Barbaros, U (Barbaros, Umut); Dinccag, A (Dinccag, Ahmet) Source: JOURNAL OF GASTROINTESTINAL SURGERY Volume: 13 Issue: 8 Pages: 1520-1523 DOI: 10.1007/s11605-009-0869- 8 Published: AUG 2009 Abstract: Single incision laparoscopic procedures are presumed to be as a step towards pure natural orifice transluminal endoscopic surgery. However, loss of requirement of any perforation of visceral organ and endoscopic equipment make this technique more popular and easily performable. Herein we report two splenectomy cases where single incision surgery (SILS) technique was performed. Two females of 28 years old and 22 years old with the diagnoses of ITP underwent single incision laparoscopic splenectomy. Preoperatively with the receival of steroid therapy, thrombocyte counts were 92,000/m(3). A 2-cm umbilical incision was used for the placement of three (5 mm) trocars. One 5-mm videoscope (30A degrees) and roticulated laparoscopic dissector/grasper were the main tools during surgical procedure. Spleen was removed with a plastic removal bag through the umbilical trocar incision. The whole procedure ended in 110 and 150 min in both cases without any problem. Two patients were discharged on third and second postoperative days with the thrombocyte counts of 174,000/m(3) and 400,000/m(3), respectively. Although there were some procedures performed with single incision technique like cholecystectomy, prostatectomy, and partial nephrectomy, as far as we are concerned this is the first report about laparoscopic splenectomy performed with single incision surgery technique. Accession Number: WOS:000268069400017 PubMed ID: 19365695 ISSN: 1091-255X Title: The characteristics of concomitant thyroid nodules cause false-positive ultrasonography results in primary hyperparathyroidism Author(s): Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim); Salmashoglu, A (Salmashoglu, Artuer); Issever, H (Issever, Halim); Aral, F (Aral, Ferihan); Tunaci, M (Tunaci, Mehtap); Ozarmagan, S (Ozarmagan, Selcuk) Source: AMERICAN JOURNAL OF OTOLARYNGOLOGY Volume: 30 Issue: 4 Pages: 239- 243 DOI: 10.1016/j.amjoto.2008.06.007 Published: JUL-AUG 2009 Abstract: Background: Concomitant thyroid nodules are the most common reason for falsepositive ultrasonography (US) results in primary hyperparathyroidism. The aims of this prospective clinical Study were to evaluate false-positive US results according to the characteristics of concomitant thyroid nodules and to determine which characteristics of thyroid nodules are important. Study design: This prospective Study included 120 consecutive patients with primary hyperparathyroidism. The patients were divided into 2 groups according to preoperative US results. Group I consisted of 32 patients with false-positive US results and group 2 consisted of 88 patients with true-positive US results. Results: The risk for false-positive US result was increased 25-fold for patients with parathyroid adenoma weight of more than 500 mg (odds ratio [OR], 25; 95% confidence interval [CI], 8.6- 74.5), 75-fold for more than I posteriorly located thyroid (OR, 75; 95% CI, 19.3-293.4), 358-fold for the presence of exophytic thyroid nodules (OR, 358; 95% Cl, 42.3-3036), and 423-fold for the presence of posteriorly located thyroid nodules (OR, 423; 95% Cl, 49-3662). Conclusion: Although there was no particular characteristic of concomitant thyroid nodules that contributes to false-positive US results, the posteriorly located thyroid nodules were the strongest Correlate for the false-positive US results to other features. (C) 2009 Elsevier Inc. All rights reserved. Accession Number: WOS:000267921100005 PubMed ID: 19563934 ISSN: 0196-0709 Title: Minimally invasive video-assisted subtotal parathyroidectomy with thymectomy for secondary hyperparathyroidism Author(s): Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim); Yildirim, A (Yildirim, Alaattin); Saricam, G (Saricam, Guelay); Yazici, H (Yazici, Halil); Ozarmagan, S (Oezarmagan, Selcuk) Source: LANGENBECKS ARCHIVES OF SURGERY Volume: 394 Issue: 3 Pages: 451- 455 DOI: 10.1007/s00423-008-0413-4 Published: MAY 2009 Abstract: Secondary hyperparathyroidism (sHPT) is common in patients with chronic renal failure. Bilateral cervical exploration is optimal for patients with sHPT. The aims of this clinical trial are to evaluate the feasibility of video-assisted subtotal parathyroidectomy as an alternative surgical treatment for sHPT. This prospective study included 12 consecutive patients with sHPT. Surgical indications included a high intact parathormone level, enlarged parathyroid glands, high bone turnover and conditions refractory to medical treatment of hypercalcemia and hyperphosphatemia. All patients underwent minimally invasive video-assisted subtotal parathyroidectomy and transcervical thymectomy. Four cervical glands were found in all patients and intrathymic glands were identified in three (25%) patients. Minimally invasive video-assisted subtotal parathyroidectomy offers an alternative method, and this technique can be performed safely for sHPT. Accession Number: WOS:000264486100006 PubMed ID: 18726112 ISSN: 1435-2443 Title: The impact of age, vitamin D(3) level, and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomy Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Temel, B (Temel, Bernal); Turkoglu, U (Turkoglu, Umit); Issever, H (Issever, Halim); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Oezarmagan, Selcuk); Tezelman, S (Tezelman, Serdar) Source: AMERICAN JOURNAL OF SURGERY Volume: 197 Issue: 4 Pages: 439- 446 DOI: 10.1016/j.amjsurg.2008.01.032 Published: APR 2009 Abstract: BACKGROUND: Hypocalcemia Caused by transient or definitive hypoparathyroidism is the most frequent complication after thyroidectomy. We aimed to compare the impact of incidental parathyroidectomy and serum vitamin D(3) level on postoperative hypocalcemia after total thyroidectomy (TT) or near total thyroidectomy (NTT). PATIENTS: Two hundred consecutive patients with nontoxic multinodular goiter treated by TT and NTT were included prospectively in the present Study. Group I (n = 49) consisted of patients with a postoperative serum calcium level <= 8 mg/dL, and group 2 to = 151) had a postoperative serum calcium level greater than 8 mg/dL. Patients were evaluated according to age, preoperative serum 9 25-hydroxy vitamin D (25-OHD) levels, postoperative serum calcium levels, incidental parathyroidectorny, and the type of thyroidectomy. RESULTS: Patients in group I (In = 49) were hypocalcemic, whereas patients in group 2 (n = 151 were normocalcemic. Preoperative serum 25-OHD) levels in group I were significantly lower than in group 2 (P < .001). The incidence of hypoparathyroidism was significantly higher following TT (13.5%) than following NTT (2.5%) (P <.05). The risk For postoperative hypocalcemia was increased 25-fold for patients older than 50 years, 28-fold for patients with a preoperative serum 25-OHD level less than 15 ng/mL, and 71-fold for patients Who underwent TT. Incidental parathyroidectomy (lid not have an impact on postoperative hypocalcemia. The highest risk of postoperative hypocalcemia was found in the patients with all of the above variables. CONCLUSIONS: Age, preoperative low serum 25-OHD, and TT are significantly associated with postoperative hypocalcemia. Patients with advanced age and low preoperative serum 25-OHD levels should be placed on calcium or vitamin D supplementation after TT to avoid postoperative hypocalcemia and decrease hospital stay. (C) 2009 Elsevier Inc. All rights reserved. Accession Number: WOS:000264999600003 PubMed ID: 19324110 ISSN: 0002-9610 Title: Risk factors of incidental parathyroidectomy after thyroidectomy for benign thyroid disorders Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Ozbey, N (Ozbey, Nese); Aral, F (Aral, Ferihan); Ozarmagan, S (Ozarmagan, Selcuk) Source: INTERNATIONAL JOURNAL OF SURGERY Volume: 7 Issue: 1 Pages: 58- 61 DOI: 10.1016/j.ijsu.2008.10.012 Published: 2009 Abstract: Background: Incidental resection of parathyroid tissue is not uncommon during thyroidectomy and may occur even in the hands of experienced thyroid surgeons. We aimed to investigate the clinical relevance of incidental parathyroidectomy and to determine which risk factors are important for it. Patients: Four hundred and forty consecutive patients with non-toxic multinodular goitre treated by total and near-total thyroidectomy were included prospectively in the present study. Patients in group 1 (n = 48) had inadvertent resection of parathyroid gland, whereas patients in group 2 (n = 392) did not have parathyroid glands removed. Results: There was a positive correlation between the incidental parathyroidectomy and total thyroidectomy (r(s) = 0.519, p = 0.0001), and thyroid pathology (r(s) = 0.338, p = 0.0001) and intrathyroid parathyroid locations. Incidental parathyroidectomy did not have an impact on postoperative hypocalcemia. The risk for incidental parathyroidectomy was increased 13-fold for patients who underwent total thyroidectomy (OR: 13.7; 95% CI:4.08-46.05), 4-fold for patients with substernal goitre (OR: 4.1; 95% CI:1.1-14.3). Conclusions: Total thyroidectomy, thyroid pathology, and intrathyroid parathyroid locations are risk factors for incidental parathyroidectomy. All established risk factors for incidental parathyroidectomy are also risk factors for postoperative hypocalcemia. Incidental parathyroidectomy during thyroid surgery may be a potential complication. (C) 2008 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. Accession Number: WOS:000208236700015 PubMed ID: 19027373 ISSN: 1743-9191 eISSN: 1743-9159 Title: The change in the principle of performing laparoscopic adrenalectomy from small to large masses Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Karaman, G (Karaman, Gulay); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Ozarmagan, Selcuk) Source: INTERNATIONAL JOURNAL OF SURGERY Volume: 7 Issue: 3 Pages: 266- 271 DOI: 10.1016/j.ijsu.2009.04.011 Published: 2009 Abstract: Background: Laparoscopic adrenalectomy has become the gold standard in most patients with adrenal tumors. It is unclear; however, at what size an adrenal neoplasm should be resected by means of an open or a laparoscopic approach. The aim of the present study was to compare the outcomes of laparoscopic adrenalectomy for large tumors with smaller tumors. Methods: A prospective study of patients who underwent adrenalectomy during the period 2006- 2009 was undertaken. The patients were divided into 2 groups according to the tumor size. Group 1 (n = 29) consisted of patients presenting tumors smaller than 5 cm in diameter; group 2 (n = 31) consisted of patients with tumors larger than 5 cm in diameter. Results: Two of the 29 tumors in group 1 (6.8%) were malignant at final histology. However, 11 of the 31 tumors in group 2 (35.4%) were malignant. There were no significant differences between operating time and complications of groups 1 and 2. The intra-operative blood loss was significantly lower in group 1 than in group 2. Conclusion: Laparoscopic adrenalectomy is a reasonable procedure for selected large adrenal tumors when a complete resection is technically feasible and there is no evidence of local invasion. (c) 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. Accession Number: WOS:000208236900022 PubMed ID: 19410021 ISSN: 1743-9191 Title: Effect of thyroid gland volume in preoperative detection of suspected malignant thyroid nodules in a multinodular goiter Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Salmashoglu, A (Salmashoglu, Artuer); Mete, O (Mete, Ozguer); Issever, H (Issever, Halim); Ozarmagan, S (Ozarmagan, Selcuk); Yilmazbayhan, D (Yilmazbayhan, Dilek); Tezelman, S (Tezelman, Serdar) Source: ARCHIVES OF SURGERY Volume: 143 Issue: 6 Pages: 558- 563 DOI: 10.1001/archsurg.143.6.558 Published: JUN 2008 Abstract: Hypothesis: The detection of suspected malignant thyroid nodules by ultrasonography is associated with thyroid gland volume and tumor size. Design: Prospective clinical trial. Setting: A tertiary referral center. Patients: Three hundred sixty-five patients with a multinodular goiter with coexistent dominant nodules. Main Outcome Measures: The correlation between thyroid gland volume and tumor size and the detection of suspected malignant thyroid nodules by ultrasonography. The incidence of thyroid carcinoma inside and outside the dominant nodules and thyroid gland volume and tumor size in suspected or unsuspected malignant thyroid nodules by ultrasonography were determined. Receiver operating characteristic analysis was used to identify the cutoffs of the tumor size and thyroid gland volume. Results: One hundred thyroid carcinomas were found in 69 (18.9%) patients. Forty-one of these carcinomas were inside the dominant nodule, whereas 59 were outside the dominant nodule. Only 9 of the 59 thyroid carcinomas outside the dominant nodules were suspected of being malignant by ultrasonography. Thyroid gland volume less than 38 mL and tumor size larger than 7mm had 48-fold (odds ratio, 48; P <.001) and 21.5-fold (odds ratio, 21.5; P <.001) increased rates, respectively, of detecting suspected malignant thyroid nodules by ultrasonography. Conclusions: Thyroid gland volume and tumor size were significantly associated with detection of suspected malignant thyroid nodules by ultrasonography. Small thyroid gland volume was associated with detection of suspected malignant thyroid nodules in multinodular goiters. Accession Number: WOS:000256795200008 PubMed ID: 18559748 Author Identifiers: Author ResearcherID Number ORCID Number Mete, Ozgur 0000-0003-0469-2801 ISSN: 0004-0010 eISSN: 1538-3644 Title: Gastric volvulus after laparoscopic left adrenalectomy - Case report Author(s): Corcione, F (Corcione, Francesco); Tricarico, F (Tricarico, Fausto); Barbaros, U (Barbaros, Umut); Marzano, E (Marzano, Ettore); Montini, F (Montini, Francesco); Trombetti, A (Trombetti, Amilcare) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 18 Issue: 2 Pages: 207- 208 DOI: 10.1097/SLE.0b013e318169ce4f Published: APR 2008 Abstract: In this era of modern technologies, laparoscopic adrenalectomy is a gold standard surgical treatment for benign adrenal lesions. However, being aware of its difficulties and their managements is a very important issue for the surgeons who are interested in minimal invasive surgery. In this article, we are presenting a case of a 57-year-old woman who has undergone laparoscopic left adrenalectomy and in the third postoperative month, had an acute gastric volvulus requiring surgical open treatment. To the best of our knowledge, this report is the first article about a gastric volvulus case after left laparoscopic adrenalectomy. Accession Number: WOS:000255219700016 PubMed ID: 18427344 ISSN: 1530-4515 Title: Impact of adenoma weight and ectopic location of parathyroid adenoma on localization study results Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Tukenmez, M (Tuekenmez, Mustafa); Issever, H (Issever, Halim); Salmaslioglu, A (Salmaslioglu, Artur); Adalet, I (Adalet, Isik); Ozarmagan, S (Oezarmagan, Selcuk); Tezelman, S (Tezelman, Serdar) Source: WORLD JOURNAL OF SURGERY Volume: 32 Issue: 4 Pages: 566- 571 DOI: 10.1007/s00268-007-9389-4 Published: APR 2008 Abstract: Although the sensitivity of preoperative localization techniques is high for solitary parathyroid adenomas, negative imaging study results are inevitable. The weight and location of the parathyroid adenoma may contribute to the negative results. We aimed to study the impact of adenoma weight and ectopic location of the parathyroid adenoma on ultrasonography and sestamibi scan results. The patients were divided into two groups according to adenoma location. Group 1 consisted of 36 patients with ectopic location, and group 2 consisted of 149 patients with normal location. Parathyroid adenoma weight and the results of imaging studies were determined in all patients. Of 185 patients operated on for hyperparathyroidism, 36 (19.4%) had ectopic parathyroid glands. There was a positive correlation between adenoma weight and positive imaging studies, whereas ectopic location did not correlate with negative imaging study results. There was no significant difference between the ectopic adenoma ratio of patients with negative and positive imaging study results. The weight of the ectopic parathyroid adenoma was significantly lower in patients with negative imaging study results than in patients with positive imaging study results (p = 0.001). According to the analysis of variance, patients with higherweight adenomas have positive imaging study results irrespective of ectopic location. For both normal and ectopic adenoma locations, adenoma weight was found only to be a factor that positively influences imaging study results. Accession Number: WOS:000253996000011 PubMed ID: 18210183 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 ISSN: 0364-2313 Title: The effect of anti-thyroid drug treatment duration on thyroid gland microvessel density and intraoperative blood loss in patients with Graves' disease Author(s): Erbil, Y (Erbil, Yesim); Giris, M (Giris, Murat); Salmaslioglu, A (Salmaslioglu, Artur); Ozluk, Y (Ozluk, Yasemin); Barbaros, U (Barbaros, Umut); Yanik, BT (Yanik, Burcu Tulumoglu); Kapran, Y (Kapran, Yersu); Abbasoglu, SD (Abbasoglu, Semra Dogru); Ozarmagan, S (Ozarmagan, Selcuk) Source: SURGERY Volume: 143 Issue: 2 Pages: 216- 225 DOI: 10.1016/j.surg.2007.07.036 Published: FEB 2008 Abstract: Background. Preoperative preparation of the patient with Graves' disease (GD) is crucial to avoid intraoperative or postoperative complications associated with anesthesia or surgery. We aimed to evaluate thyroid blood flow and microvessel density in patients with GD according to antithyroid drug (ATD) treatment, preoperatively. Method. Forty-three patients were divided into two groups according to the ATD type. Patients in group 1 (n = 25) were treated with methimazole, whereas patients in group 2 (n = 18) were treated with propylthiouracil, preoperatively. Blood flow through the thyroid arteries was measured by color flow Doppler ultrasonography. The microvessel density (MVD) was assessed immunohistochemically and via Western blot analysis using the level of CD-34expression in thyroid tissue. Results. There was a positive correlation between blood loss and thyroid volume (r(s) = 0.953, P = 0001) and blood flow (r(s) = 0.720, P = .0001) and CD-34 expression (r(s) = 0.331, P = .03) and MVD (r(s) = 0.442, P = .003). No correlation was observed between ATD type and thyroid vascularity. In patients with longer treatment duration before operation, thyroid vascularity was significantly lower relative to patients with shorter treatment durations. According to. logistic regression analysis, longer treatment duration had a 142-fold decreased rate of intraoperative blood loss independent of ATD type. Conclusion. Preoperative ATD treatment duration may predict intraoperative blood loss during thyroidectomy. Longer treatment duration might be useful in reducing intraoperative bleeding, allowing better visualization and preservation of the nerves and parathyroid glands. Accession Number: WOS:000253172300014 PubMed ID: 18242338 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 Ozluk, Yasemin 0000-0002-7191-0488 ISSN: 0039-6060 Title: The positive effect of adenoma weight and oxyphil cell content on preoperative localization with Tc-99m-sestamibi scanning for primary hyperparathyroidism Author(s): Erbil, YI (Erbil, Yesim); Kapran, Y (Kapran, Yersu); Issever, H (Issever, Halim); Barbaros, U (Barbaros, Umut); Adalet, I (Adalet, Isik); Dizdaroglu, F (Dizdaroglu, Ferhunde); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Ozarmagan, Selcuk); Tezelman, S (Tezelman, Serdar) Source: AMERICAN JOURNAL OF SURGERY Volume: 195 Issue: 1 Pages: 34- 39 DOI: 10.1016/j.amjsurg.2007.01.040 Published: JAN 2008 Abstract: Background: Although the sensitivity of sestamibi scanning (MIBI) is high in patients with solitary parathyroid adenomas, negative sestamibi scan results are inevitable. The exact mechanism of visualization of abnormal and hyperfunctioning parathyroid tissue is not yet clear. The aims of this clinical study were (1) to evaluate positive and negative sestamibi scan results with regard to adenoma weight and oxyphil cell content and (2) to compare the effects of adenoma weight and oxyphil cell content on the results of sestamibi scanning. Patients: The patients were divided in 2 groups according to their sestamibi scan results. Group I consisted of 27 patients with positive sestamibi scan results, and group 2 consisted of 20 patients with negative sestamibi scan results. Parathyroid adenoma weight and oxyphil cell content were determined in all patients. Results: The weight and oxyphil cell content of the parathyroid adenomas in the patients of group I were significantly higher than those in the patients of group 2 (P = .001). An adenoma weight > 600 mg and an oxyphil cell content > 20% increased the rate of obtaining a positive sestamibi scan result 10- and 4-fold, respectively. Conclusions: Both adenoma weight and oxyphil cell content were found to significantly correlate with positive sestamibi scan results. In patients with high-weight adenomas, adenoma weight was the most significant factor in obtaining positive MIBI scan results, whereas in patients with low adenoma weights, high oxyphil cell content was the most significant factor in obtaining positive MIBI scan results. (c) 2008 Excerpta Medica Inc. All rights reserved. Accession Number: WOS:000251968300008 PubMed ID: 18082541 ISSN: 0002-9610 Title: Clinical and radiological features of adrenal cysts Author(s): Erbil, Y (Erbil, Yesim); Salmaslioglu, A (Salmaslioglu, Artuer); Barbaros, U (Barbaros, Umut); Bozbora, A (Bozbora, Alp); Mete, O (Mete, Oezguer); Aral, F (Aral, Ferihan); Ozarmagan, S (Oezarmagan, Selcuk) Source: UROLOGIA INTERNATIONALIS Volume: 80 Issue: 1 Pages: 31- 36 DOI: 10.1159/000111726 Published: 2008 Abstract: Adrenal cysts are very rare lesions, usually asymptomatic or without characteristic symptoms. They are classified as pseudocysts, endothelial cysts, epithelial cysts or parasitic cysts. Although pseudocysts are reported to be the most common clinically recognized adrenal cysts in surgical series, endothelial cysts are more common in autopsy series. We studied 15 consecutive patients with adrenal cysts who underwent surgical resection at our institution from 1990 to 2005. Of 15 patients with adrenal cysts, 10 had pseudocysts, 3 epithelial cysts, 1 an endothelial cyst and 1 a parasitic cyst. In conclusion, a better understanding of cystic adrenal masses is necessary to recognize true adrenal cysts and differentiating them from adrenal carcinoma or adenoma by demonstrating the foci of cystic or degenerative changes. Copyright (c) 2008 S. Karger AG, Basel. Accession Number: WOS:000252591000006 PubMed ID: 18204230 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 Mete, Ozgur 0000-0003-0469-2801 ISSN: 0042-1138 Title: Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis Author(s): Erbil, Y (Erbil, Yesim); Giris, M (Giris, Murat); Abbasoglu, SD (Abbasoglu, Semra Dogru); Barbaros, U (Barbaros, Umut); Yanik, BT (Yanik, Burcu Tulumoglu); Necefli, A (Necefli, Ahmet); Olgac, V (Olgac, Vakur); Toker, GA (Toker, Guelcin Aykac) Source: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Volume: 22 Issue: 11 Pages: 1852-1858 DOI: 10.1111/j.1440- 1746.2007.04838.x Published: NOV 2007 Abstract: Background and Aim: Ulcerative colitis is a chronic inflammatory disease of the colon and rectum. Although the precise etiology of ulcerative colitis remains unknown, it is believed to involve an abnormal host response to endogenous or environmental antigens, genetic factors, and oxidative damage. The aim of the present study was to investigate whether heme oxygenase-1 (HO-1) induction by octreotide could protect against oxidative and inflammatory damage from induced colitis. Methods: Rats received octreotide 50 mu g/kg per day intraperitoneally for 5 days before 2,4,6 trinitrobenzene sulfonic acid (TNBS) solution administration and for 15 days following TNBS solution administration. Rats were killed on day 21, and colonic malondialdehyde (MDA) levels, glutathione (GSH) levels and HO-1 expression were measured. Nuclear factor (NF)-kappa B and HO-1 expression was evaluated by immunohistochemical examination of the colonic tissue. Results: Rats with TNBS-induced colitis had significantly increased colonic MDA levels and HO- 1 expression in comparison to the control group. Octreotide treatment was associated with increased HO-1 expression and GSH levels, but decreased MDA levels. Histopathological examination revealed that the intestinal mucosal structure was preserved in the octreotide-treated group. In addition, treatment with octreotide significantly increased HO-1 expression and decreased NF-kappa B expression by immunohistochemistry when compared to the TNBSinduced colitis group. Conclusion: Octreotide appears to have protective effects against colonic damage in TNBSinduced colitis. This protective effect is, in part, mediated by modification of the inflammatory response and the induction of HO-1 expression. Accession Number: WOS:000249924100030 PubMed ID: 17914959 Author Identifiers: Author ResearcherID Number ORCID Number Olgac, Vakur B-2823-2014 ISSN: 0815-9319 Title: How I do it: Radio-guided nonpalpable metastatic lymph node localization in patients with recurrent thyroid cancer Author(s): Tukenmez, M (Tukenmez, Mustafa); Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Dural, C (Dural, Cem); Salmaslioglu, A (Salmaslioglu, Artuer); Aksoy, D (Aksoy, Deniz); Mudun, A (Mudun, Ayse); Ozarmagan, S (Ozarmagan, Selcuk) Source: JOURNAL OF SURGICAL ONCOLOGY Volume: 96 Issue: 6 Pages: 534- 538 DOI: 10.1002/jso.20873 Published: NOV 1 2007 Abstract: The detection of nonpalpable recurrent thyroid carcinoma has increased due to the use of imaging techniques in time. This report is to investigate whether preoperative injection of a radiotracer under ultrasound guidance is useful in nonpalpable recurrent thyroid carcinoma. The neck of two patients with recurrent thyroid carcinoma was scanned with the probe to localize the area of maximal radioactivity allowing appropriate location of the incision over the lesion. After the lymph nodes were removed, radioactivity was measured in the lesion bed to confirm the success of the dissection. In conclusion, the radio-guided nonpalpable lesion localization technique can be performed safely for the detection and excision of metastatic foci. Accession Number: WOS:000250986800017 PubMed ID: 17680637 Author Identifiers: Author ResearcherID Number ORCID Number Dural, Ahmet Cem P-2006-2014 0000-0003-3479-725X ISSN: 0022-4790 Title: Laparoscopic treatment of a wandering partial colonic obstruction - Report of a case Author(s): Barbaros, U (Barbaros, Umut); Tukenmez, M (Tukenmez, Mustafa); Erbil, Y (Erbil, Yesim); Dinccak, A (Dinccak, Ahmet); Tiryaki, B (Tiryaki, Betuel); Ozarmagan, S (Ozarmagan, Selquk); Mercan, S (Mercan, Selcuk); Budak, D (Budak, Demir) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 17 Issue: 5 Pages: 462- 464 DOI: 10.1097/SLE.0b013e3180ca9b54 Published: OCT 2007 Abstract: Wandering spleens are rarely encountered ectopic localizations of the spleen. They are either congenital or acquired owing to the lack of or weakening of the major splenic ligaments. Herein, we present a female patient who was admitted to our hospital with the complaint of abdominal distension and chronic constipation. We performed laparoscopic splenectomy in this case for the diagnosis of a wandering spleen located in the right upper quadrant. The accepted treatment of this pathology is splenopexy unless there is no necrosis of the organ. Minimal invasive procedures should be the primary choice in the treatment of this entity. Accession Number: WOS:000250420700026 PubMed ID: 18049417 ISSN: 1530-4515 Title: An infrequent cause of upper gastrointestinal tract bleeding: "Dieulafoy's lesion" Author(s): Yanar, H (Yanar, Hahan); Dolay, K (Dolay, Kemal); Ertekin, C (Ertekin, Cemalettin); Taviloglu, K (Taviloglu, Korhan); Ozcinar, B (Ozcinar, Beyza); Guloglu, R (Guloglu, Recep); Barbaros, U (Barbaros, Umut) Source: HEPATO-GASTROENTEROLOGY Volume: 54 Issue: 76 Pages: 1013- 1017 Published: JUN 2007 Abstract: Background/Aims: Dieulafoy's lesions are uncommon sources of upper gastrointestinal tract bleeding. Endoscopists must be aware of these lesions when evaluating patients with upper gastrointestinal tract bleeding. Methodology: The aim of this study is to analyze the results of active bleeding or recurrently bleeding Dieulafoy's lesions treated either by endoscopic injection therapy (EIT) or endoscopic band ligation (EBL). Fifteen patients who had active bleeding due to Dieulafoy's lesions were evaluated retrospectively with respect to demographic properties, comorbidities, endoscopic therapy procedures, and the success rate of the procedure: Results: The incidence of Dieulafoy's lesions was 4.5% in all cases of upper gastrointestinal tract bleeding. Among the 15 patients there were nine men and six women with a median age of 52 years (25-84 years). Eleven of these lesions were located in the stomach, two were in the duodenum, and two were in the distal esophagus. Eight patients were initially treated by EIT and seven patients had EBL therapy. There was no recurrent bleeding in any of the patients treated with EBL, but five patients (62.5%) treated with EIT bled again and were treated secondarily with EBL. Two of these patients required surgical intervention and one died on the 15th day of surgery due to myocardial infarction. No endoscopyrelated complications were detected. Conclusions: Endoscopic methods should be the first choice in treating bleeding Dieulafoy's lesions. Both EIT and EBL are successful methods for achieving initial hemostasis. However, EIT therapy has a higher re-bleeding rate. EBL is a safe and effective method for the treatment of bleeding Dieulafoy's lesions. Accession Number: WOS:000247568100008 PubMed ID: 17629028 Author Identifiers: Author ResearcherID Number ORCID Number DOLAY, KEMAL M-2032-2016 0000-0001-9776-8945 ISSN: 0172-6390 Title: Effect of lugol solution on thyroid gland blood flow and microvessel density in the patients with Graves' disease Author(s): Erbil, Y (Erbil, Yesim); Ozluk, Y (Ozluk, Yasemin); Giris, M (Giris, Murat); Salmaslioglu, A (Salmaslioglu, Artur); Issever, H (Issever, Halim); Barbaros, U (Barbaros, Umut); Kapran, Y (Kapran, Yersu); Ozarmagan, S (Ozarmagan, Selcuk); Tezelman, S (Tezelman, Serdar) Source: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Volume: 92 Issue: 6 Pages: 2182-2189 DOI: 10.1210/jc.2007- 0229 Published: JUN 2007 Abstract: Context: Although some endocrine surgeons administer Lugol solution to decrease thyroid gland vascularity, there is still not an agreement on its effectiveness. Objective: The aims of this clinical trial are to evaluate thyroid blood flow and microvessel density in patients with Graves' disease who received Lugol solution treatment preoperatively. Design: This was a prospective clinical trial. Setting: This clinical trial took place at a tertiary referral center. ethod: Thirty-six patients were randomly assigned to receive either preoperative treatment with Lugol solution (group 1, n = 17) or no preoperative treatment with Lugol solution (group 2, n = 19). Main Outcome Measures: Blood flow through the thyroid arteries of patients with Graves' disease was measured by color flow Doppler ultrasonography. The microvessel density (MVD) was assessed by immunohistochemical and Western blot analysis of the level of expression of CD-34 in thyroid tissue. The weight and blood loss of the thyroid gland were measured in all patients. Results: The mean blood flow, MVD, CD-34 expression, and blood loss in group 1 patients were significantly lower than those in group 2 patients. There was a negative correlation between Lugol solution treatment and blood flow (rs = 0.629; P = 0.0001), blood loss (rs = -0.621; P = 0.0001), MVD (rs = -0.865; P = 0.0001), and CD-34 expression (rs = -0.865; P = 0.0001). According to logistic regression analysis, Lugol solution treatment resulted in a 9.33-fold decreased rate of intraoperative blood loss. Conclusion: Preoperative Lugol solution treatment decreased the rate of blood flow, thyroid vascularity, and intraoperative blood loss during thyroidectomy. Accession Number: WOS:000247061700031 PubMed ID: 17389702 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 Ozluk, Yasemin 0000-0002-7191-0488 ISSN: 0021-972X eISSN: 1945-7197 Title: Handheld gamma probe used to detect accessory spleens during initial laparoscopic splenectomies Author(s): Barbaros, U (Barbaros, Umut); Dinccag, A (Dinccag, Ahmet); Erbil, Y (Erbil, Yesim); Mercan, S (Mercan, Selcuk); Sanli, Y (Sanli, Yasemin); Adalet, I (Adalet, Isik); Kucukkaya, R (Kucukkaya, Reyhan) Source: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES Volume: 21 Issue: 1 Pages: 115-119 DOI: 10.1007/s00464-006-0001- z Published: JAN 2007 Abstract: Background: Preoperative determination of the accessory spleen still is a major factor in the failure of both laparoscopic and conventional techniques. This study aimed to evaluate the practicability and efficacy of a handheld gamma probe in identifying accessory spleens at the initial intervention. Methods: This study evaluated 17 patients undergoing laparoscopic splenectomy attributable to benign hematologic disorders. All the patients had preoperative ultrasonography, computed tomography (CT) scan, and nuclear scintigraphic examination of the abdominal cavity to assess the size of the spleen, and to determine the existence of the accessory spleen or spleens. For all the patients, a handheld gamma probe count was used intraoperatively as an adjuvant method to define the presence and location of the accessory splenic tissue. Control nuclear scintigraphic examinations of all the patients were performed 1 month after the surgical procedure. Results: In two cases, intraoperatively accessory splenic tissue was detected by gamma probe, confirming the preoperative CT findings for the patients. One of these patients had three accessory spleens, although preoperative CT scan showed only two of them. However, by the help of the gamma probe, a third spleen located retroperitoneally was defined. For two patients, laparoscopic exploration and handheld gamma probe count did not identify any accessory splenic tissue, although preoperative CT scan indicated accessory spleens. For detecting accessory splenic tissue, the sensitivities of the studied techniques were 0% for ultrasonography, 75% for CT scan, 0% for preoperative nuclear scintigraphy, 75% for laparoscopic exploration, and 100% for perioperative gamma probe examination. Conclusion: Preoperative imaging methods for accessory spleen determination still have limited benefits because of their limited sensitivity. Thus, the handheld gamma probe technique may be an adjuvant method for laparoscopic exploration ensuring that no accessory splenic tissue is missed during the initial surgical treatment of benign hematologic disorders. Accession Number: WOS:000243106500023 PubMed ID: 16960669 ISSN: 0930-2794 Title: The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal Author(s): Tanrikulu, S (Tanrikulu, Sevda); Erbil, Y (Erbil, Yesim); Ademoglu, E (Ademoglu, Evin); Issever, H (Issever, Halim); Barbaros, U (Barbaros, Umut); Kutluturk, F (Kutluturk, Faruk); Ozarmagan, S (Ozarmagan, Selcuk); Tezelman, S (Tezelman, Serdar) Source: ENDOCRINE Volume: 30 Issue: 3 Pages: 377-381 DOI: 10.1007/s12020-006-0017- 0 Published: DEC 2006 Abstract: Graves' disease (GD) is a multifactorial disease that develops as a result of complex interactions between genetic and environmental factors. The aim of our study is to determine the frequency of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) A/G and TG C/T exon 33 SNPs (Tg E33SNP) in GD and to evaluate the relation between recurrence and these polymorphisms. A total of 187 subjects, including 97 previously treated GD patients and 90 age and gender matched control subjects were studied. We examined the relationship between the A/G and C/T polymorphism and various clinical and laboratory variables among patients with GD. TT genotype frequency in the GD patients was significantly higher than the controls. Number of recurrent patients was significantly higher in AG and GG carriers in comparison to AA carriers (57% and 45% vs 14%,p = 0.0001). CTLA-4 AG genotype had an eightfold (OR: 8.050; 95 % CI: 2.87-22.5; p = 0.0001) and GG genotype had a sevenfold (OR: 7.025; 95% CI: 1.67-29.4; p = 0.007) increase in the risk of recurrence in the patients with GD. In conclusion, early interpretation for definitive treatment procedures (i.e., radioactive iodine or surgery) may be considered in the patients with G allielle and E33SNP of Tg gene is conformed the susceptibility to GD in a Turkish population and having TT genotype increases the susceptibility to GD. Accession Number: WOS:000246018300017 PubMed ID: 17526951 ISSN: 0969-711X Title: Determination of oxidative stress in thyroid tissue and plasma of patients with Graves' disease Author(s): Ademoglu, E (Ademoglu, Evin); Ozbey, N (Oezbey, Nese); Erbil, Y (Erbil, Yesim); Tanrikulu, S (Tanrikulu, Sevda); Barbaros, U (Barbaros, Umut); Yanik, BT (Yanik, Burcu Tulumoglu); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Oezarmagan, Selcuk) Source: EUROPEAN JOURNAL OF INTERNAL MEDICINE Volume: 17 Issue: 8 Pages: 545- 550 DOI: 10.1016/j.ejim.2006.04.013 Published: DEC 2006 Abstract: Background: The aim of our study was to evaluate the oxidant/antioxidant status of thyroid tissue in Graves' disease (GD) patients and to compare the results of GD thyroid tissue with plasma of patients and healthy controls. Methods: We studied 25 consecutive patients with GD hyperthyroidism who underwent surgical treatment. The patients were divided into groups according to the duration of antithyroid drug treatment, the type of antithyroid drugs used, the presence of ophthalmopathy, and recurrence after a complete course of antithyroid drugs. Thiobarbituric acid-reacting substances (TBARS), glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, and total thiol (t-SH) content of tissue and plasma samples were determined. Results: TBARS concentrations were found to be significantly increased in GD patients' plasma compared with controls' plasma (0.1 +/- 0.02 nmol/mg protein vs. 0.062 +/- 0.01 nmol/mg protein). Significantly decreased t-SH concentrations were measured in GD patients' plasma compared with controls (8.26 +/- 1.9 nmol/mg protein vs. 13.03 +/- 3.3 nmol/mg protein). Tissue TBARS, t-SH, GPx, and SOD measurements in GD patients indicated significantly increased concentrations compared with the plasma levels of patients. Patients with shorter treatment duration before the operation had significantly increased plasma and tissue TBARS and decreased plasma and tissue t-SH concentrations. Patients on propylthiouracil treatment had significantly lower plasma and tissue concentrations of TBARS than patients on methimazole. Patients with recurrence had significantly higher plasma and tissue TBARS and lower plasma and tissue t-SH concentrations than patients treated for the first time. Conclusions: In euthyroid GD patients on antithyroid drugs, increased oxidative stress and a compensatory increase in the antioxidant defense system are more prominent in thyroid tissue than in plasma. Patients who relapsed had markers indicating increased oxidative stress. Thus, ongoing autoimmunity may contribute to increased oxidative stress in GD patients, even in the euthyroid state. (C) 2006 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. Accession Number: WOS:000243291900004 PubMed ID: 17142172 ISSN: 0953-6205 Title: Value of parathyroid hormone assay for preoperative sonographically guided parathyroid aspirates for minimally invasive parathyroidectomy Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Salmasliglu, A (Salmasliglu, Artur); Tunaci, M (Tunaci, Mehtap); Ozbey, N (Ozbey, Nese); Bozbora, A (Bozbora, Alp); Ozmarmagan, S (Ozmarmagan, Selcuk) Source: JOURNAL OF CLINICAL ULTRASOUND Volume: 34 Issue: 9 Pages: 425- 429 DOI: 10.1002/jcu.20275 Published: NOV-DEC 2006 Abstract: Purpose. The key to successful parathyroid surgery is accurate preoperative tumor localization. This study investigates the use of ultrasound (US)-guided parathyroid fine needle aspiration (FNA) as a confirmatory diagnostic method in patients with hyperparathyroidism undergoing minimally invasive parathyroidectomy. Methods. Patients were selected for minimally invasive parathyroidectomy based on the finding of a single parathyroid adenoma identified with US and/or sestamibi scans and confirmation of the suspected parathyroid lesion via FNA and parathyroid hormone (PTH) assay. The value of aspirate obtained from the thyroid gland intraoperatively served as the negative control. Results. A total of 56 tissue FNAs were performed in 27 patients. US detected masses suggestive of parathyroid lesion in all 27 patients, and 31 US-guided FNAs were performed. No complications related to the procedure were noted. Intraoperatively, FNA was performed in the thyroids of 25 patients undergoing minimally invasive parathyroidectomy. Aspirates from lesions subsequently confirmed as having developed from the parathyroid gland had a mean PTH level of 4,677 +/- 123 pg/ml (range, 3,600 - 5,000 pg/ml), which was significantly higher than thyroid aspirates, which yielded a mean PTH level of 48 +/- 7 pg/ml (range, 5-57 pg/ml). The sensitivity of US and sestamibi scans in the detection of abnormal parathyroid glands was 88% and 77%, respectively. The sensitivity of US-guided FNA in confirming the parathyroid origin of a lesion was 100%. Conclusion. US-guided FNA for PTH assay can be performed safely for the confirmation of lesions identified with preoperative US for the selection of patients eligible for minimally invasive parathyroidectomy. (c) 2006 Wiley Periodicals, Inc. Accession Number: WOS:000243291500001 PubMed ID: 17078029 ISSN: 0091-2751 Title: The advantage of near-total thyroidectomy to avoid postoperative hypoparathyroidism in benign multinodular goiter Author(s): Erbil, Y (Erbil, Yesim); Barbaros, U (Barbaros, Umut); Salmaslioglu, A (Salmaslioglu, Artur); Yanik, BT (Yanik, Burcu Tulumoglu); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Ozarmagan, Selcuk) Source: LANGENBECKS ARCHIVES OF SURGERY Volume: 391 Issue: 6 Pages: 567- 573 DOI: 10.1007/s00423-006-0091-z Published: NOV 2006 Abstract: Background In recent years, total or near-total thyroidectomy has emerged as a surgical option to treat patients with multinodular goiter, especially in endemic iodine-deficient regions. The aim of this study was to compare the complication rates of total and near-total thyroidectomy in multinodular goiter and the incidence of thyroid cancer requiring radioactive iodine ablation and completion thyroidectomy between groups. Study design Patients with euthyroid multinodular goiter without any preoperative suspicion of malignancy, history of familial thyroid cancer, or previous exposure to radiation were randomized (according to a random table) to total thyroidectomy (group 1, n=104) and near-total thyroidectomy leaving less than 2 g (group 2, n=112). Results There were no persistent complications. The incidence of transient hypoparathyroidism in group 1 (26%) was significantly higher than in group 2 (9.8%) (p < Ce0.001). The rate of asymptomatic hypocalcemia in group 2 (7.4%) was lower than in group 1 (27%) (p < 0.001). The incidence of papillary cancer was 9.6% in group 1 and 12.5% in group 2 (p > 0.05). None of the patients underwent completion thyroidectomy before ablative therapy. Ten patients were found to have the histological criteria for radioactive iodine ablation. Of these 10 patients, four were in group 1 and six were in group 2 (p > 0.05). Conclusion In conclusion, we recommend near-total thyroidectomy in multinodular goiter instead of total or subtotal thyroidectomy. While near-total thyroidectomy and total thyroidectomy obviate the need for completion thyroidectomy in incidentally found thyroid cancer, and while there is no difference in the rate of recurrent laryngeal nerve palsy between the two methods, near-total thyroidectomy causes a significantly lower rate of hypoparathyroidism compared to total thyroidectomy. Accession Number: WOS:000241612300005 PubMed ID: 17021791 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 ISSN: 1435-2443 Title: The use of LigaSure in patients with hyperthyroidism Author(s): Barbaros, U (Barbaros, Umut); Erbil, Y (Erbil, Yesim); Bozbora, A (Bozbora, Alp); Deveci, U (Deveci, Ugur); Aksakal, N (Aksakal, Nihat); Dinccag, A (Dinccag, Ahmet); Ozarmagan, S (Ozarmagan, Selcuk) Source: LANGENBECKS ARCHIVES OF SURGERY Volume: 391 Issue: 6 Pages: 575- 579 DOI: 10.1007/s00423-006-0082-0 Published: NOV 2006 Abstract: Background Thyroidectomies of hyperthyroidic patients are known to be more bloodspattered than the operations performed for euthyroid nodular diseases and require careful hemostasis. Our purpose was to evaluate the efficacy of the use of LigaSure in patients with hyperthyroidism. Materials and methods Between January 2004 and October 2005, 100 patients underwent total or near-total thyroidectomy. Bipolar vessel ligation system (LigaSure) was the choice of modality for hemostasis in half of these patients, and the conventional suture ligation technique was used for the rest. The following data were evaluated non-randomized and prospectively in this study: patients demographics, thyroid pathology, operative duration, presence of complications, and the duration of the hospital stay. Comparisons of the data were evaluated by the Wilcoxon and chisquare tests. Results Among the patients of the LigaSure group, 14 patients were detected to have hyperthyroidism (seven patients with Graves' disease and another seven patients with multinodular toxic goiter), while 36 patients were found to be euthyroidic. The durations of the operation time and of the hospital stay of the patients in the LigaSure group were significantly lower than the conventional thyroidectomy group (p < 0.05). The complication rates of the LigaSure and conventional thyroidectomy groups were 4 and 6%, respectively (p > 0.05). Conclusions The use of LigaSure as an operative technique in the treatment of Graves' disease and toxic goiter is a safe and effective modality that provides a shorter hospital stay and a shorter operation time as well. Accession Number: WOS:000241612300006 PubMed ID: 16955301 Conference Title: International Symposium on Modern Technologies in Thyroid Surgery Conference Date: FEB 10-11, 2006 Conference Location: Halle, GERMANY Author Identifiers: Author ResearcherID Number ORCID Number Deveci, Ugur 0000-0003-4449-1190 ISSN: 1435-2443 Title: The effect of melatonin on TNBS-induced colitis Author(s): Necefli, A (Necefli, Ahmet); Tulumoglu, B (Tulumoglu, Burcu); Giris, M (Giris, Murat); Barbaros, U (Barbaros, Umut); Gunduz, M (Gunduz, Mucteba); Olgac, V (Olgac, Vakur); Guloglu, R (Guloglu, Recep); Toker, G (Toker, Gulcin) Source: DIGESTIVE DISEASES AND SCIENCES Volume: 51 Issue: 9 Pages: 1538- 1545 DOI: 10.1007/s10620-005-9047-3 Published: SEP 2006 Abstract: Ulcerative colitis is a multifactorial inflammatory disease of the colon and rectum with an unknown etiology. The present study was undertaken to investigate the effect of melatonin administration on oxidative damage and apoptosis in 2,4,6-trinitrobenzene sulfonic acid (TNBS)- induced colitis. Rats were divided into four groups as follows: Group 1 (n=8)-TNBS colitis; Group 2 (n=8)-melatonin, 10 mg/kg/day ip, for 15 days in addition to TNBS; Group 3 (n=8)-melatonin alone, 10 mg/kg/day ip, for 15 days; and Group 4 (n=8)-isotonic saline solution, 1ml/rat ip, for 15 days (sham control group). Colonic myeloperoxidase (MPO) activities, malondialdehyde (MDA) levels, and glutathione (GSH) levels are indicators of oxidative damage, while caspase-3 activities reveal the degree of apoptosis of the colonic tissue. In all TNBS-treated rats, colonic MPO activity and MDA levels were found to be increased significantly compared to those in the sham group. Colonic MPO activity and MDA levels were significantly lower in the melatonin treatment group compared to TNBS-treated rats. GSH levels of colonic tissues were found to be significantly lower in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly increased GSH levels compared to those in TNBS-treated rats. Caspas-3 activity of colonic tissues was found to be significantly higher in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly decreased caspase-3 activity compared to that in TNBS-treated rats. These results imply a reduction in mucosal damage due to anti-inflammatory and anti-apoptotic effects of melatonin. Accession Number: WOS:000240377500005 PubMed ID: 16927145 Author Identifiers: Author ResearcherID Number ORCID Number Olgac, Vakur B-2823-2014 ISSN: 0163-2116 Title: Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery Author(s): Erbil, Y (Erbil, Yesim); Ademoglu, E (Ademoglu, Evin); Ozbey, N (Oezbey, Nese); Barbaros, U (Barbaros, Umut); Yanik, BT (Yanik, Burcu Tulumoglu); Salmaslioglu, A (Salmaslioglu, Artur); Bozbora, A (Bozbora, Alp); Ozarmagan, S (Oezarmagan, Selcuk) Source: WORLD JOURNAL OF SURGERY Volume: 30 Issue: 9 Pages: 1665- 1671 DOI: 10.1007/s00268-005-0681-x Published: SEP 2006 Abstract: Background: The widespread use of ultrasound, computerized tomography, and magnetic resonance imaging has led to an increase in the number of incidental adrenal masses identified. Asymptomatic incidentally discovered adrenal masses may indicate that subclinical Cushing syndrome (SCS) is not uncommon. We aimed to evaluate the cardiovascular risk of patients with SCS before and after surgery. Methods: An autonomous cortisol-producing tumor was detected in 11 of 94 patients with adrenal incidentaloma between 1995 and 2005. Twenty-eight patients suffering from classical Cushing syndrome (CS) associated with unilateral adrenocortical adenoma, who were treated at our department in the same period, served as a control group. Cardiovascular risk factors such as blood pressure, body mass index, and lipid profile were evaluated before and 1 year after surgery. Results: The frequency of hypertension (61% versus 63%), obesity (46% versus 55%), diabetes mellitus (50% versus 36%), hypercholesterolemia (39% versus 36%), and low HDL cholesterol (28% versus 36%) were not significantly different between CS and SCS patients, respectively. Adverse cardiovascular risk profile improved 1 year after adrenalectomy in both groups, although the changes were not significant with respect to body mass index, frequency of diabetes, and hyperlipidemia in SCS patients. But frequency of systolic/diastolic hypertension decreased significantly in this group. Conclusions: These findings indicate that the increased incidence of cardiovascular risk factors commonly observed in classical CS, is also present in SCS. Unilateral adrenalectomy does not always lead to significant improvements in cardiovascular risk profile in SCS. Accession Number: WOS:000240331900014 PubMed ID: 16927063 Author Identifiers: Author ResearcherID Number ORCID Number Salmaslioglu, Artur 0000-0002-8576-7942 ISSN: 0364-2313 Title: Minimally invasive surgery in the treatment of splenosis Author(s): Barbaros, U (Barbaros, Umut); Dinccag, A (Dinccag, Ahmet); Kabul, E (Kabul, Esin) Source: SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES Volume: 16 Issue: 3 Pages: 187-189 DOI: 10.1097/00129689-200606000- 00016 Published: JUN 2006 Abstract: Splenosis has been serious etiologic reason in the recurrence of benign hematologic diseases after elective open or laparoscopic splenectomy. Although, the incidince of splenosis in patients splenectomized for trauma is high, as long as they are asymptomatic, they do not require surgical treatment. Herein, we report a case of idiopathic thrombocytopenic purpura recurrence due to splenosis 5 years after the initial laparoscopic splenectomy. Laparoscopic treatment of splenosis was performed successfully. Accession Number: WOS:000238897900015 PubMed ID: 16804467 ISSN: 1530-4515 eISSN: 1534-4908 Title: Role of vascular endothelial growth factor in the prognosis of papillary thyroid cancer Author(s): Bozbora, A (Bozbora, Alp); Erbil, Y (Erbil, Yesim); Kapran, Y (Kapran, Yersu); Ture, N (Ture, Nevzat); Barbaros, U (Barbaros, Umut); Ozarmagan, S (Ozarmagan, Selcuk) Source: ENDOCRINOLOGIST Volume: 16 Issue: 3 Pages: 168- 171 DOI: 10.1097/01.ten.0000220297.71375.ec Published: MAY-JUN 2006 Abstract: Vascular endothelial growth factor (VEGF) induces proliferation of endothelial cells, stimulates angiogenesis, and increases vascular permeability. Increased VEGF expression has been associated with poor clinical outcomes in many malignancies. Several recent reports have documented overexpression of VEGF in papillary thyroid cancer. We studied the relationship between increased expression of VEGF and an increased risk of recurrence. The aims of this study were to determine whether immunohistochemical expression of VEGF is related to local and distant recurrence of papillary thyroid cancer and to evaluate the relationship between hypervascularization and VEGF expression in papillary thyroid carcinoma. VEGF expression was examined immunohistochemically in 45 papillary carcinomas. Ten patients with normal thyroid glands who underwent surgery between 1991 and 1992 were used as controls. All patients were followed for 12 years. Fifteen of the patients had local and distant recurrences. VEGF immunostaining was evaluated semiquantitatively by a pathologist. The difference between the recurrent (n = 15) and nonrecurrent (n = 30) carcinomas was statistically significant (P = 0.001). VEGF expression was also stronger in papillary thyroid carcinomas than in normal thyroid tissues (P = 0.001). There was a statistically significant correlation among the tumor size, regional recurrence, distant metastasis, and the VEGF expression. These data indicate that VEGF staining is strongly associated with an increased frequency of recurrence in papillary thyroid cancer and that the immunohistochemical profile of the expression may be used as a marker for predicting which tumors have metastatic potential. Accession Number: WOS:000238052800013 ISSN: 1051-2144 eISSN: 1539-9192 Title: Malignant phyllode tumor metastatic to the duodenum Author(s): Asoglu, O (Asoglu, Oktar); Karanlik, H (Karanlik, Hasan); Barbaros, U (Barbaros, Umut); Yanar, H (Yanar, Hakan); Kapran, Y (Kapran, Yersu); Kecer, M (Kecer, Mustafa); Parlak, M (Parlak, Mesut) Source: WORLD JOURNAL OF GASTROENTEROLOGY Volume: 12 Issue: 10 Pages: 1649- 1651 DOI: 10.3748/wjg.v12.i10.1649 Published: MAR 14 2006 Abstract: Phyllode tumor (PT) is extremely rare tumor of the breast. Distant metastasis occurs in 10-20% of patients with malignant phyllode tumor. The most common sites of metastases are the lungs and bones. Although theoretically any organ may have metastasis, an isolated duodenum metastasis has not been documented as yet in the English-language literature. We report herein a case with a isolated duodenal metastasis from PT of breast in a 31 year-old-woman who underwent right mastectomy 4 years before because of the recurrent malignant PT She presented to our hospital with massive upper gastrointestinal bleeding. Clinical evaluation revealed a huge mass originated from duodenum. Urgent laparotomy and pancreaticoduodenectomy were carried out in order to remove the bleeding duodenal mass. The pathologic examination of the resected specimen showed a malignant spindle cell tumor consistent with metastatic malignant PT. Our case of gastrointestinal bleeding due to an isolated duodenal metastasis as a result of hematogenous spread from malignant phyllode tumor of breast is unique in the English literature and pancreaticoduodenectomy is a curative treatment for patients with isolated duodenal involvement. (C) 2006 The WJG Press. All rights reserved. Accession Number: WOS:000239995600027 PubMed ID: 16570365 ISSN: 1007-9327
ARTICLES PRESENTED AT INTERNATIONAL SCIENTIFIC MEETINGS AND PUBLISHED IN PROCEEDINGS BOOKS
§ Taviloğlu, K., Günay, K., Ertekin, C., Barbaros, U., Güloğlu, R. ve M. Kurtoğlu, “Complex Hepatic Injuries: Our Current Trends, ” 4th European Congress ‘Trauma and Emergency’, Pisa, Italy, 2000. § Tavioğlu, K., Ertekin, C., Günay. K., Barbaros, U., Rozanes, I., Güloğlu, R. ve M. Kurtoğlu, “A Case of Ileocolic Artery Pseusdo- Aneurysm Due To a Crush Injury Following The DUzce Earthquake, ” 4th European Congress ‘Trauma and Emergency’, Pisa, Italy, 2000. § Tavioğlu, K., Günay, K., Okan, İ., Barbaros, U., Ertekin, C., Güloğlu, R. ve M. Kurtoğlu, “Our Experience with Crush Injuries Following The Marmara Earthquake Disaster, ” 4th European Congress ‘Trauma and Emergency, Pisa, Italy, 2000. § Türe, N., Bozbora, A., Barbaros, U., Erbil, Y. ve S. Özarmağan, “Incidence of Papillary Microcarcınoma and Treatment Modalities, ” 10th Annıversiary of Eurosurgery and Turkish Surgical Congress, 51, Istanbul, Turkey, 2000. § Barbaros, U., Deveci, U., Emek, E., Seven, R., Bozbora, A. ve S. Mercan, “Recent results of laparoscopic ventral hernia management, ” 3rd Mediterranean and Middle Eastren Endoscopic Surgery Congress, 120,Istanbul, Turkey, 2000. § Barbaros, U., Bozbora, A., Erbil, Y., Özarmağan, S. ve S. Mercan, “Laparoscopic insulinoma enucleation(case), ” 3rd Mediterranean and Middle Eastren Endoscopic Surgery Congress, 124,Istanbul, Turkey, 2000. § Bilsel, Y., Bulut, T., Yamaner, S., Buğra, D. ve U. Barbaros, “Thrombocytopenia as an alarming sign for septicemia in a surgical ward, ” 13th Int. Intensive Care Symposium, 22, Istanbul, Turkey, 2001. § Barbaros, U., Erbil, Y., Bozbora, A., Deveci, U., Aksakal, N., Dinççağ, A. ve S. Özarmağan, “Ligasure Use in Hyperthyroidism, ” Symposium of Modern Technologies in Thyroid Surgery, 51, Halle/S, Germany, 2006. § Barbaros, U., Dinççağ, A., Deveci, U., Erbil, Y., Yanar, F., Seven, R. ve S. Mercan, “Prospective Comparison of Laparoscopic and Conventional Splenectomies, ” 6th Mediterranean and Middle Eastren Endoscopic Surgery Congress, 45, Malaga, Spain, 2006. § Barbaros, U., Deveci, U., Seven, R., Asoglu, O., Erbil, Y., Özarmağan, S., Mercan, S. ve D. Budak, “Laparoscopic Ventral Hernia Treatment: Results of 30 cases, ” 6th Mediterranean and Middle Eastren Endoscopic Surgery Congress,76,Malaga, Spain,2006. § Asoglu, O., Barbaros, U. ve Y. Kapran, “Laparoscopic treatment of terminal ileum carcinoid tumor, ” 21th Biennial Congress of International Society of the University of Colon and Rectal Surgeons, 117, Istanbul, 2006. § Asoglu, O., Müslümanoğlu, M., İğci, A., Özmen, V., Keçer, M., Parlak, M., Barbaros, U., Altıntoprak, F., Matlım, T., ve H. Karanlık, “What are the dificulties of Laparoscopic Rectal Cancer Surgery? ” 21th Biennial Congress of International Society of the University of Colon and Rectal Surgeons, 149, Istanbul, 2006. § Barbaros, U., Dinççağ, A., Tükenmez, M., Erbil, Y., Bozbora, A., Özarmağan, S. ve S. Mercan, “Laparoscopic treatment of Insulinomas, ” Update in Endocrine Surgery:2nd Workshop of the European Society of Endocrine Surgeons,392, Viyana, Austria, 2007.
ARTICLES PUBLISHED IN NATIONAL PEER-REVIEWED JOURNALS
§ Eminoğlu, L., Erbil, Y., Barbaros, U., Türkoğlu, Ü., Olgaç, O. ve S. Mercan, “Radyasyon Enteritinde Vitamin E ve Selenyumun Etkisi (Deneysel Çalışma),” Çağdaş Cerrahi Dergisi, 2, 67-71 (2000). § Bilsel, Y, Bulut, T., Barbaros, U. ve D. Buğra, “Cerrahi Servislerde Sepsis Belirteci Olarak Trombositopeninin Önemi,” Çağdaş Cerrahi Dergisi, 3, 164-169 (2002). § Kayacan, S.M., Kazancıoğlu, R., Oflaz, H., Enkür, A., Kayacan, D., Barbaros, U. ve M. Demiryont, “An interesting case of renal osteodystrophy transforming to fibrous dysplasia, ” Medical Bulletin of İstanbul Medical Faculty, 1, 42-47,(2002). § Bozbora, A., Coşkun, H., Erbil, Y., Barbaros. U, S. Özarmağan, “Morbid Obezite Tedavisinde Laparoskopi Ayarlanabilir Silikon Mide Bandı (Lap-Band®)Uygulaması,” Endoskopik Laparoskopik Minimla İnvaziv Cerrahi Degisi, 9, 123-130, (2002). § Erbil, Y., Bozbora, A., Barbaros, U., Özbey, N., Kapran. Y, ve S. Özarmağan, “Papiller Mikrokarsinomlara Yaklaşım,” Çağdaş Cerrahi Dergisi, 17, 30-34, (2003). § Erbil, Y. ve U. Barbaros, “İntraabdominal Enfeksiyonlara Cerrahi Yaklaşım,” Hipokrat Dergisi, 11, 42-44 (2003). § Barbaros, U. ve A. Bozbora, “Cerrahi Alan İnfeksiyonları,” Hipokrat Dergisi, 11, 35-39 (2003). § Erbil, Y., Bozbora, A., Barbaros, U., Köneş, O., Özbey, N. ve S. Özarmağan, “Sürrenal İnsidentalomalara Yaklaşım,” Çağdaş Cerrahi Dergisi, 2, 85-90 (2003). § Ertekin, C. ve U. Barbaros, “Korozif Madde Alımına Bağlı Gastrointestinal Sistem Yanıkları, ” Türkiye Klinikleri Cerrahi Tıp Bilimleri, 4, 79-83 (2005). § U. Barbaros, “Cerrahi Alan İnfeksiyonları,” Türkiye Klinikleri Cerrahi Tıp Bilimleri, 18,14-15 (2006). § Barbaros, U., Deveci, U., Eren, T., Tulumoğlu, B., Seven, R. Ve S. Mercan, “Morgagni Hernisinin Laparoskopik Onarımı: Olgu Sunumu,” Endoskopik Laparoskopik ve Minimal İnvaziv Cerrahi Dergisi, 13, 72-76, (2006). § Barbaros, U., Tükenmez, M., Gündüz, M., Erçetin, C., Çıtlak, G., Erbil, Y., Bozbora, A. ve S. Özarmağan, “Sürrenal Gangliyonörom: Klinik ve Radyolojik Özelliklerin İnsidental Sürrenal Kitlelerle Karşılaştırılması,” Endokrinolojide Diyalog, 3,117-122 (2007). § Barbaros, U., Tükenmez, M., Tulumoğlu Yanık, B., İlhan, B., Çelik, T., Erbil, E., Bozbora, A. ve S. Özarmağan, “Paratiroid Karsinomu: Klinik ve Laboratuar Özelliklerinin Paratiroid Adenomları ile Karşılaştırılması,” Endokrinolojide Diyalog, 2,79-84 (2007). § Bostan, M.S., Aksu, K., Tükenmez, M., Barbaros, U., Erbil, Y. ve S. Özarmağan, “Atipik Klinik Seyir Gösteren Retroperitoneal Paraganglioma Olgusu,’” Endokrinolojide Diyalog, 4, 182-184 (2007).
ARTICLES PRESENTED AT NATIONAL SCIENTIFIC MEETINGS AND PUBLISHED IN PROCEEDINGS BOOKS
§ Barbaros, U., Günay, K., Taviloğlu, K. ve K. Ayalp, “Özofagus varis kanamalarında band ligasyonu,” 3rd National Trauma and Emergency Surgery Congress,132,31 Ağustos-4 September, Antalya, 1999. § Barbaros, U., Günay, K., Taviloğlu, K. ve C. Ertekin, “Seyrek G.rülen Üst Gastrointestinal Sistem Kanama Nedeni: Cameron Ülseri (2 Case reports),” 3rd National Trauma and Emergency Surgery Congress 134,31 August-4 September, Antalya, 1999. § Cabıoğlu, N., Günay, K., Barbaros, U., Taviloğlu, K. ve C. Ertekin, “Üst Gastrointestinal Kanmalı Mallory- Weiss Sendromlu İki Vakada Başarılı Endoskopik Ligasyon Tedavisi,” 3rd National Trauma and Emergency Surgery Congress,133, 31 August-4 September, Antalya, 1999. § Buluş, H.H., Ertekin, C. ve U. Barbaros, “Üst Ekstermite ve El Yanıklarında Rehablitasyon,” 3rd National Trauma and Emergency Surgery Congress,133, 31 August- 4 September, Antalya, 1999. § Taviloğlu, K., Güloğlu, R., Barbaros, U., Mengü., S., Türe, N., Ertekin, C. ve Ö. Türel, “Kolorektal yaralanmalarda stoma? Primer Onarım?” 2. Bölgesel Travma ve Acil Cerrahi Kongresi, 8, 27-30 Eylül, Diyarbakır, 2000. § Taviloğlu, K., Ertekin, C., Güloğlu, R., Barbaros, U, Mengü., S. ve M. Kurtoğlu, “TRK Sonuçlarının Genel Değerlendirilmesi,” 2nd Regional Trauma and Emergency Surgery Congress, 27- 30 September, Diyarbakır, 2000. § Barbaros, U., Asoğlu, O., Taviloğlu, K. ve E. Şen, “Acute Mechanical Colonic Obstruction Due to Anastomotic Stricture(Case Report),” 9th Turkish National Congress of Colorectal Surgery,172,9-13 September, Antalya, 2001. § Barbaros, U., Özarmağan, Ö., Erbil, Y., Bozbora, A., Çakar, N., Eraksoy, H., Kapran, Y. ve B. Kıran, “CO2 İnsüflasyonu ile Yapılan Pnömoperitoneumun ve Mekanik Ventilasyon Parametrelerinin ( PEEP Uygulamasının) Batın İçi İnfeksiyonun Sistemik Yayılımı Üzerine Etkileri,” 2nd National Congress of Experimental Surgery ,94,20-21 September, Ankara, 2003. § Barbaros, U., Dinççağ, A., Özgen, G., Başpınar, İ. ve U. Deveci, “Aksiller kitle ile başvuran hastada okült meme karsinomu,” 7th National Breast Disease Congress,186,16-19 October, Antalya, 2003. § Barbaros, U., Dinççağ, A., Olgaç, V., Deveci, U. ve İ. Başpınar, “Memenin Anjiosarkomu,” § 7th National Breast Disease Congress,185,16-19 October, Antalya, 2003. § Barbaros, U., İmren, M.A., Uğraş, B., Erbil, Y., Bozbora, A., Özarmağan, S. ve Y. Kapran, “Bilateral Adrenal Lenfoma: Olgu Sunumu,” National Surgery Congress,388,26-30 May, Antalya, 2004. § Barbaros, U., Cimşit, B., Deveci, U., Erbil, Y., Bozbora, A., Özarmağan, S. ve Y. Kapran, “Adrenal Kistik Lenfanjiomatozis,” National Surgery Congress,388,26-30 May, Antalya, 2004. § Barbaros, U., Deveci, U., Cimşit, B., Erbil, Y., Bozbora, A., Özarmağan, S. ve Y. Kapran, “Adrenal Gangliyonöroma: Olgu Sunumu,” National Surgery Congress,389,26-30 May, Antalya, 2004. § İmren, M.A., Avtan, L., Barbaros, U., Başpınar, İ., Dural, C. ve U. Çevikbaş, “Pneumoperitoneumun Kolon Anastomozunun İyileşmesi Üzerine Etkileri,” National Surgery Congress,426,26-30 May, Antalya, 2004. § Eren, E., Akyıldız, H., Barbaros, U. ve C. Ertekin, “ Hipertonik Solüsyonun Akut Nekrotizan Pankreatite Etkileri,” National Surgery Congress,194,26-30 May, Antalya, 2004. § Barbaros, U., Deveci, U., Asoğlu, O., Erbil, Y, Bozbora, A., Seven, R., Mercan, S. ve D. Budak, “Laparoskopik İnsizyonel Herni Tedavisinde Erken Sonuçlarımız,” 7th National Endoscopic Laparoscopic Surgery Congress, 120, İstanbul, 2005. § Barbaros, U., Dinççağ, A., Deveci, U. ve T. Çelik, “Laparoskopik Parastomal Herni Onarımı: Olgu Sunumu,” 7th National Endoscopic Laparoscopic Surgery Congress, 119, İstanbul, 2005. § Topuz, S., Çorbacıoğlu, A., İyibozkurt, A.C., Barbaros, U., Akhan, S.E., Salihoğlu, Y., Bengisu, E. ve S. Berkman, “İntraperitoneal kemoterapi kateter komplikasyonu:barsağa penetre olan kateter,” 10th National Gynecology Oncology Congress, 64,19-23 Nisan, Antalya, 2006. § Deveci, U., Tükenmez, M., Barbaros, U., Erbil, Y., Bozbora, A., Seven, R., Özarmağan, S. ve S. Mercan, “Laparoskopik ve Açık Adrenalektominin Karşılaştırılması,” National Surgery Congress, 85, 24-28 May, Antalya, 2006. § Deveci, U., Yanar, F., İlhan, M., Barbaros, U., Erbil, Y., Bozbora, A. ve S. Özarmağan, “Zor tiroidektomilerde endotrakeal tüp elektromyografisi,” National Surgery Congress, 86, 24- 28 May, Antalya, 2006. § Tihan, D., Deveci, U., Barbaros, U., Erbil, Y., Bozbora, A. ve S. Özarmağan, “Langerhans Hücreli Histiyositozis’in Gastrointestinal Tutulumu: Olgu Sunumu,” National Surgery Congress, 235, 24-28 May, Antalya, 2006. § Barbaros, U., Dinççağ, A., Deveci, U., Erbil, Y., Yanar, F., Seven, R. ve S. Mercan, “Selim Hematolojik Hastalıklarda, Laparoskopik Splenektomi ile Açık Splenektominin Karşılaştırılması,” National Surgery Congress, 240, 24-28 May, Antalya, 2006. § Asoğlu, O., Müslümanoğlu, M., İğci, A., Özmen, V., Keçer, M., Parlak, M., Barbaros, U., Altıntoprak, F., Matlım, T. ve H. Karanlık, “Laparoskopik Rektal Kanser Cerrahisinde Teknik Zorluklar,” National Surgery Congress, 42, 24-28 May, Antalya, 2006. § Demirel, T., Eren, E., Barbaros, U., Yanar, H., Asoğlu, O. ve K. Taviloğlu, “ Kolonoskopi sonrası oluşan karaciğer ve dalak yaralanması: Konservatif Tedavi Edilen Bir Vakanın Sunumu,” National Surgery Congress, 348, 24-28 May, Antalya, 2006. § Asoğlu, O., Barbaros, U., Altıntoprak, F., Matlım, T., Kapran, Y., Sağlam, S. ve E. Sağlam, “Lokal İleri Evre Özofagus Tüm.rlerinde Kime Neoadjuvan Kemoradyoterapi Kime Cerrahi Tedavi Uygulanmalı? Olgu Sunumları, ” National Surgery Congress, 176, 24-28 May, Antalya, 2006. § Barbaros, Deveci, U., Dilege, E. , Tükenmez. M., Sağıroğlu, T., Erbil,Y., Dinççağ, A., Seven, R., Özarmağan, S. ve S. Mercan, “Ventral herni tamirinde yama tespiti için n-butil siyanoakrilat kullanımı (deneysel çalışma),” 2nd National Hernia Congress, 17-20 May, Antalya, 2007. § Barbaros, U., Tükenmez, M., Dinççağ, A., Erbil, Y. ve S. Mercan, “Laparoskopik Splenektomi Sırasında Aksesuar Dalak Tespitinde Yeni Bir Yardımcı Teknik: Gama Prob Kullanımı,” 88th National Endoscopic Laparoscopic Surgery Congress,64,1-4 July, Antalya, 2007. § Barbaros, U., Tükenmez, M., Dural, C., Hünerli, K., Dinççağ, A, Erbil, Y., Seven, R. ve S. Mercan, “El Yardımlı Laparoskopik Splenektomi Tekniği,” 8th National Endoscopic Laparoscopic Surgery Congress, 65, 1-4 July, Antalya, 2007. § Barbaros, U., Deveci, U., Tükenmez, M., Erbil, Y., Seven, R., Dinççağ, A., Mercan, S. ve S. Özarmağan, “Laparoskopik Ventral Hernilerde Kullanılan Farklı Yamaların Klinik Sonuçları,” 8th National Endoscopic Laparoscopic Surgery Congress, 58,1-4 July, Antalya, 2007. OTHER PUBLICATIONS § Kurtoğlu, M., Taviloğlu, K., Güloğlu, R., Barbaros, U., Necefli, A. ve Yanar. H, “Warfarin Induced Skin Necrosis: Presentation of Two Cases,” European Journal of Vascular and Endovascular Surgery Extra, 2:91-93 (2001). Başpınar, İ., Deveci, U., Kapran, Y., Bozbora, A., Aral, F. ve Özarmağan. S, “Hydatid Cyst of the Thyroid Gland: Two Case Reports,” Infectous Diseases in Clinical Practice,13: 318-320 (2005). § Barbaros, U., Erbil, Y., Bozbora, A., Deveci, U., Özarmağan, S. ve Kapran. Y, “ Primary Adrenal Lymphoma Presenting as Bilateral Adrenal Masses, ” The Endorinologist. 16: 75-76 (2006). § Bozbora, A., Erbil, Y., Kapran, Y., Türe, N., Barbaros, U. ve Özarmağan. S, “Role of Vascular Endothelial Growth Factor in the Prognosis of Papillary Thyroid Cancer,” The Endorinologist, 16: 168-171 (2006).
TRANSLATIONS OF BOOK CHAPTERS
§ Özarmağan, S. ve U. Barbaros, Hipertiroidizm.Ergüney S, Çiçek Y. Güncel Cerrahi Tedavi. Avrupa Tıp Kitapçılık, (2001). § Özarmağan, S. ve U. Barbaros, Mide. Özarmağan S, İğci A. Cerrahi Atlası. Avrupa Tıp Kitapçılık, (2002). § U. Barbaros, Laringoskopi: Direkt, İndirekt, Esnek(Fileksibl) Fiberoptik Teknikler. Erbil Y. Acil ve Ayaktan Tedavi İşlemleri. Nobel Bookstore, (2003). § U. Barbaros, Hızlı Entübasyon. Erbil Y. Acil ve Ayaktan Tedavi İşlemleri. Nobel Bookstore, (2003). § U. Barbaros, Endotrakeal Entübasyon. Erbil Y. Acil ve Ayaktan Tedavi İşlemleri. Nobel Bookstore, (2003). § U. Barbaros, Krikotiroidotomi. Erbil Y. Acil ve Ayaktan Tedavi İşlemleri. Nobel Bookstore, (2003). § Tunalı, V. ve U. Barbaros, Akalazya ve Diğer Özofagus Motilite Bozuklukları. Erbil Y, Değerli Ü. Mayo Kliniği Gastrointestinal Cerrahi Sistem Cerrahisi. Nobel Bookstore, (2004). § U. Barbaros, Endokrin problemler. Erbil Y. Yoğun Bakım Esasları. Nobel Bookstore, (2005). § Erbil, Y. ve U. Barbaros, Meme başı akıntısı. Özmen M, Baksan S. Cerrahide karar verme. Güneş Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, Jinekomasti. Özmen M, Baksan S. Cerrahide karar verme. Güneş Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, Dominant Meme Kitlesi. Özmen M, Baksan S. Cerrahide karar verme. Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, Gizli Meme Lezyonları. Özmen M, Baksan S. Cerrahide karar verme. Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, Erken Meme Kanseri. Özmen M, Baksan S. Cerrahide karar verme. Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, İleri Meme Kanseri. Özmen M, Baksan S. Cerrahide karar verme. Güneş Medical Publishing, (2007). § Erbil, Y. ve U. Barbaros, Nüks Meme Kanseri. Özmen M, Baksan S. Cerrahide karar verme. Güneş Medical Publishing, (2007).
WRITING OF NATIONAL BOOK CHAPTER
§ Erbil, Y. ve U. Barbaros, ‘Diaphragmatic Diseases and Gastroesophageal Reflux,’ Değerli Ü, Erbil Y. Nobel Bookstore, (2005). § Erbil, Y. ve U. Barbaros, Parathyroid diseases. Değerli Ü, Erbil Y. General Surgery. Nobel Bookstore, (2006). § Bozbora, A. ve U. Barbaros, Rare Methods. Orhan Y, Bozbora A. Obesity, Istanbul Medical Publishing, (2008). § Barbaros, U. ve A. Emre, Pankreas Endokrin Tüm.rleri. Emre A. Hepato-Pancreato-Bilier Surgery, Istanbul Medical Publishing.
WRITING OF INTERNATIONAL BOOK CHAPTER
§ Single-Access Laparoscopic Surgery: Current Applications and Controversies 2014 .Editor: Giusto Pignata,Francesco Corcione,umberto bracale. Chapter-11 Single-Access Laparoscopic Approach for Pancreatic Surgery CITATIONS
§ Gunay, K., Cabioglu, N., Barbaros, U., Taviloglu, K. ve C. Ertekin, “Endoscopic ligation for patients with active bleeding Mallory-Weiss tears,” Surg Endosc,11:1305-7 (2001). (Citations: 4) § Ertekin, C., Taviloglu, K., Barbaros, U., Guloglu, R. ve K. Dolay, “ Endoscopic band ligation: alternative treatment method in nonvariceal upper gastrointestinal hemorrhage, ” J Laparoendosc Adv Surg Tech A,1:41-5 (2002). (Citations: 6) § Doğru-Abbasoğlu, S., Mutlu-Türkoğlu, U., Türkoğlu, S., Erbil, Y., Barbaros, U., Uysal, M. ve G. Aykaç-Toker, “ Glutathione S-transferase-pi in malignant tissues and plasma of human colorectal and gastric cancers,” J Cancer Res Clin Oncol, 2:91-5 (2002). (Citations:5) § Ademoglu, E., Erbil, Y., Tam, B., Barbaros, U., Ilhan, E., Olgac, V. ve Ü. Mutlu-Turkoglu, “ Do vitamin E and selenium have beneficial effects on trinitrobenzenesulfonic acid-induced experimental colitis,” Dig Dis Sci, 1:102-8 (2004). (Citations:10) § Bozbora, A., Coskun, H., Barbaros, U., Sari, S. ve O. Asoglu, “ The effects of gastric bands of different synthetic materials on the gastric and esophageal mucosa: an experimental study,” Obes Surg,2:246-52 (2004). (Citations: 5) § Barbaros, U., Ozarmagan, S., Erbil, Y., Bozbora, A., Cakar, N., Eraksoy, H., Kapran, Y. ve B. Kiran, “ Effects of pneumoperitoneum created through CO2 insufflation and parameters of mechanical ventilation (PEEP application) on systemic dissemination of intraabdominal infections,” Surg Endosc,3:501-7 (2004). (Citations: 1) § Bozbora, A., Barbaros, U., Erbil, Y., Ozarmagan, S. Ve S. Mercan, “ Is laparoscopic enucleation the gold standard in selected cases with insulinoma?” J Laparoendosc Adv Surg Tech A, 4:230-3 (2004). (Citations: 1) § Barbaros, U., Erbil, Y., Kapran, Y., Bozbora, A., Ozarmagan, S. ve B. Bilgiç, “ Lymphoepithelial cyst: a rare cystic tumor of the pancreas which mimics carcinoma,” JOP,5:392-4 (2004). (Citations: 1) § Erbil, Y., Bozbora, A., Barbaros, U., Ozarmağan, S., Azezli, A. ve S. Molvalilar, “ Surgical management of substernal goiters: clinical experience of 170 cases,” Surg Today, 9 :732-6 (2004). (Citations:5) § Erbil, Y., Oztezcan, S., Giriş, M., Barbaros, U., Olgaç, V., Bilge, H., Kü.ücük, H. ve G. Toker, “The effect of glutamine on radiation-induced organ damage,” Life Sci, 4:376-82 (2005). (Citations: 7) § Barbaros, U., Iyibozkurt, AC., Gulluoglu, M., Barbaros, M., Erbil, Y., Tunali, V. ve S. Mercan, “Endometriotic umbilical port site metastasis after laparoscopy, ” Am J Obstet Gynecol, 5:1761-3 (2005). (Citations: 2) § Bozbora, A., Barbaros, U., Kaya, H., Erbil, Y., Kapran, Y., Ozbey, N. ve S. Özarmagan, “Thyroid metastasis of malignant melanoma, ” Am J Clin Oncol, 6:642-3 (2005). (Citations: 1) § Olgaç, V., Erbil, Y., Barbaros, U., Oztezcan, S., Giriş, M., Kaya, H., Bilge, H., Güler, S. ve G. Toker, “The efficacy of octreotide in pancreatic and intestinal changes:radiation-induced enteritis in animals, ” Dig Dis Sci, 1:227-32 (2006). (Citations: 1) § Barbaros, U., Dinççağ, A. ve E. Kabul, “Minimally invasive surgery in the treatment of splenosis, ” Surg Laparosc Endosc Percutan Tech, 3:187-9 (2006). (Citations:1) § Ozbey, N., Erbil, Y., Ademoğlu, E., Ozarmağan, S., Barbaros, U. ve A. Bozbora, “Correlations between vitamin D status and biochemical/clinical and pathological parameters in primary hyperparathyroidism, ” World J Surg,3:321-6 (2006). (Citations:2) § Giriş, M., Erbil, Y., Oztezcan, S., Olgaç, V., Barbaros, U., Deveci, U., Kirgiz, B., Uysal, M. ve G.A. Toker, “The effect of heme oxygenase-1 induction by glutamine on radiationinduced intestinal damage: the effect of heme oxygenase-1 on radiation enteritis, ” Am J Surg, 4:503-9 (2006). (Citations: 1) § I17. Erbil, Y., Barbaros, U., Yanik, B.T., Salmaslioğlu, A., Tunaci, M., Adalet, I., Bozbora, A. ve S. Ozarmağan, “Impact of gland morphology and concomitant thyroid nodules on preoperative localization of parathyroid adenomas, ” Laryngoscope, 4:580-5 (2006). (Citations: 1) § Abbasoğlu, SD., Erbil, Y., Eren, T., Giriş, M., Barbaros, U., Yücel, R., Olgaç, V., Uysal, M. ve G. Toker, “The effect of heme oxygenase-1 induction by octreotide on radiation enteritis, ” Peptides, 6:1570-6 (2006). (Citations: 1) § Ademoğlu, E., Ozbey, N., Erbil, Y., Tanrikulu, S., Barbaros, U., Yanik, B.T., Bozbora, A. ve S. Ozarmağan, “Determination of oxidative stress in thyroid tissue and plasma of patients with Graves' disease, ” Eur J Intern Med, 8:545-50 (2006). (Citations:1) § Erbil. Y., Ademoğlu, E., Ozbey, N., Barbaros, U., Yanik, B.T., Salmaslioğlu, A., Bozbora, A. ve S. Ozarmağan, “Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery, ” World J Surg,9:1665-71 (2006). (Citations:2) § Necefli, A., Tulumoğlu, B., Giriş, M., Barbaros, U., Gündüz, M., Olgaç, V., Güloğlu, R. ve G. Toker, “The effect of melatonin on TNBS-induced colitis, ” Dig Dis Sci, 9:1538-45 (2006). (Citations: 1) § Erbil, Y., Barbaros, U., Salmaslioglu, A., Tunaci, M., Ozbey, N., Bozbora, A. ve S. Özarmagan, “Value of parathyroid hormone assay for preoperative sonographically guided parathyroid aspirates for minimally invasive parathyroidectomy, ” J Clin Ultrasound, 9:425- 9 (2006). (Citations:1) § Barbaros, U., Asoglu, O., Seven, R., Erbil, Y., Dinccag, A., Deveci, U., Ozarmagan, S. ve S. Mercan, “The comparison of laparoscopic and open ventral hernia repairs: a prospective randomized study, ” Hernia, 1:51-6 (2007). (Citations:4)